老年非小细胞肺癌根治术患者抑郁对其预后及免疫功能的影响  

Analysis of the Effect of Depression in Senile Patients with Non-small Cell Lung Cancer Treated with Radical Surgery on Prognosis and Immune Function

作　　者：蒋海蓉[1] 毛蓓[1] 邓炜[1] 

机构地区：[1]解放军第一六九医院(湖南师范大学附属湘南医院),421002

出　　处：《实用癌症杂志》2016年第2期249-251,共3页The Practical Journal of Cancer

摘　　要：目的探讨老年非小细胞肺癌患者的抑郁状态对非小细胞肺癌根治术后患者的预后及免疫功能的影响。方法选择诊断为非小细胞肺癌的老年患者86例,按照是否伴有抑郁分为观察组32例及对照组54例。2组患者均给予胸腔镜肺癌根治术,并于术后给予常规化疗,观察2组患者的1年、3年、5年生存率及复发转移率,同时观察患者化疗前后的免疫功能指标的变化水平。结果观察组患者的1年生存率、3年生存率均低于对照组、转移复发率高于对照组,差异均具有统计学意义(P<0.05),而2组患者的5年生存率比较无统计学差异(P>0.05)。观察组患者化疗前后CD3+、CD4+以及CD4+/CD8+与NK的变化水平均显著低于对照组患者,差异均具有统计学意义(P<0.05),而CD8+水平的改变无显著性差异(P>0.05)。结论老年非小细胞肺癌患者在中晚期常常伴有抑郁情绪,同时抑郁状况与其生存率下降、转移复发率增加以及免疫功能减退具有一定相关性。在治疗过程中应对患者进行心理干预以提高患者的预后及免疫功能。Objective To investigate the effect of depression in senile patients with non-small cell lung cancer treated with radical surgery on prognosis and immune function. Methods 86 cases of senile patients with non-small cell lung cancer were divided into the observation group（ with 32 cases） and the control group（ 54 cases） according to whether they were complicated with depression. The 2 groups of patients were given thoracoscopic lung cancer radical surgery and routine postoperative chemotherapy. 1-,3-,5-year survival rates and recurrence rates were observed in the 2 groups,as well as the changes of immune function indexes in patients before and after chemotherapy. Results 1-,3-year survival rates and recurrence rates in the observation group were significantly higher than those of the control group,there had significant difference（ P〈 0. 05）. 5-year survival rate showed no significant difference between the 2 groups（ P 〉0. 05）. CD3 ＋,CD4 ＋,CD4 ＋ / CD8 ＋ and NK change levels in the control group were significantly lower than those of the control group,the differences were statistically significant（ P〈 0. 05）.While no significant changes of CD8 ＋ level were observed（ P 〉0. 05）. Conclusion Depression is often complicated in elderly patients with non-small cell lung cancer in advanced stage. Simultaneously,depression status has a certain relevance with reduced survival rate,increased recurrence rate and metastasis rate and the impairment of the immune system. Psychological intervention should be employed to improve the prognosis and immune function of patients in the process of treatment.

关 键 词：老年 非小细胞肺癌 根治术 抑郁 免疫功能 预后 

分 类 号：R734.2[医药卫生—肿瘤]