神经纤毛蛋白-1在口腔鳞状细胞癌中的表达及意义  

Neoropilinl （NRP-1） Expression and Significance in Oral Squamous Cell Carcinoma

作　　者：廖小欢 卢子正[2] 

机构地区：[1]广东省汕头市潮阳区大峰医院口腔科,广东汕头515154 [2]广东省汕头大学第二附属医院口腔科,广东汕头515065

出　　处：《医学临床研究》2016年第1期123-125,共3页Journal of Clinical Research

摘　　要：【目的】探讨神经纤毛蛋白-1（Neuropilin-1，NRP-1）在口腔鳞状细胞癌中的表达及意义。【方法】收集42例口腔鳞状细胞癌、癌旁正常组织作为实验标本，用免疫组织化学方法检测NRP-1原位表达情况，采用RT—PCR检测NRP—1 mRNA在口腔鳞状细胞癌、癌旁组织中的表达情况。【结果】本组42例口腔鳞状细胞癌组织中NRP-1均为高表达，42例癌旁正常组织中的NRP-1表达均呈阴性；癌组织NRP-1mRNA为（0．59±0．15），显著高于癌旁正常组织（0．43±0．17），且两者相比较差异具有显著性（P〈0．05）；〉3am的口腔鳞状细胞癌NRP-1 mRNA为（0．63±0．1）显著高于≤3cm的组织；周围组织及淋巴结转移的NRP-1 mRNA表达为（0．67±0．20），显著高于局部无转移的组织，且两者相比较差异具有显著性（P〈0．05）。【结论】口腔鳞状细胞癌中NRP-1为高表达，且可能参与口腔鳞状细胞癌的生长、转移过程中。[Objective]To investigate the expression and significance of Neuropilinl （NRP-1） in oral squamous cell carcinoma. [Methods]The data of 42 cases of oral squamous cell carcinoma, and adjacent normal tissue was used as exper- imental speciment, for immunohistochemical examination of NRP-1 and its expression in oral squamous cell carcinoma. Paracancerous RT-PCR was used in the detection of NRP-1RNA. [Results]In this group, 42 cases of oral squamous cell carcinoma tissues showed high expression of NRP-1, 42 cases of adjacent normal tissue expression of NRP-1 in cancer tissues were negative. NRP-lmRNA （0.59±0.5） was significantly higher than that in normal tissues （0.43±0.17） with significant differences （ P〈0.05）. Oral squamous cell carcinoma 〉3cm NRP-1 mRNA （0.63±0.1） was significantly higher than that of less than that of 〈3cm organization. The surrounding tissue and lymph node metastasis of NRP-1 mRNA expression for （0.67±0.20） were significantly higher than that of local metastasis tissue, with the difference being significantly difference （ P 〈0.05）. [Conclusion]NRP-1 oral squamous cell carcinoma for expression, growth, and metastasis and may be involved in oral squamous cell carcinom.

关 键 词：神经纤毛蛋白质1/生物合成 口腔肿瘤/病理学 肿瘤 鳞状细胞/病理学 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]