体部伽马刀联合重组人血管内皮抑素治疗老年晚期非小细胞肺癌的临床观察  

Clinical observation of body-gamma knife combined with recombinant human endostatin injection （Endostar） as the therapy in the elderly patients with advanced non-small cell lung cancers

作　　者：马丽丽[1] 阿衣夏木古丽·艾则孜[1] 柳江[1] 罗健[2] 

机构地区：[1]新疆维吾尔自治区人民医院肿瘤科,乌鲁木齐830001 [2]中国医学科学院北京协和医学院肿瘤医院,国家癌症中心肿瘤内科,北京100021

出　　处：《中国医师杂志》2016年第1期11-13,共3页Journal of Chinese Physician

基　　金：新疆自治区人民医院院内基金（20130118）

摘　　要：目的 探讨体部伽马刀联合重组人血管内皮抑素（恩度）治疗老年晚期非小细胞肺癌的疗效和安全性.方法 38例高龄非小细胞肺癌患者按治疗方法分为2组：A组17例为体部伽马刀联合恩度治疗组,B组21例为单用体部伽马刀治疗组,其中恩度以15 mg/d加入生理盐水500 ml中匀速缓慢静脉滴注,维持3～4h,第1～14天连续给药,间歇7d;静滴恩度同时联合体部伽玛刀治疗,21 d为1个周期.体部伽马刀治疗,治疗总剂量为36 ～48 Gy,治疗次数10～ 12次,5次/周.结果 A组肿瘤病灶治疗有效率（ORR）58.82％,疾病控制率（DCR） 88.24％,1年生存率47.06％;B组ORR 57.14％,DCR 80.95％,1年生存率38.09％.两组不良反应主要为骨髓抑制及消化道反应,但相比较差异无统计学意义（P＞0.05）.A组在近期疗效（ORR、DCR）上与B组结果相似（P＞0.05）;1年生存率前者高于后者（P＜0.05）.两组患者生活质量都有部分改善,两组差异无统计学意义（P＞0.05）.结论 体部伽玛刀联合恩度治疗老年晚期非小细胞肺癌具有较好的近、远期疗效,生活质量明显改善,两者具有协同作用,安全性亦较好.Objective To explore the efficacy and safety of human recombinant vascular endothelial inhibition （en） combined with gamma knife in the treatment of elderly advanced non-small cell lung cancer patents.Methods Totally 38 cases of senile non-small cell lung cancer patients were divided into two groups：A group was treatment group with 17 cases of recombinant human endostatin combined with gamma knife,group B was control group with 21 cases of patients receiving body gamma knife alone.Recombinant human endostatin was given intravenously 15 mg per day in 500 ml of saline for 3 ～ 4 hours for 14 days a cycle,and the total dose of body gamma knife therapy was 36 ～ 48 Gy/10 ～ 12f.Results The response rate （RR） of groups A and B were 58.82% and 57.14% without statistical difference.One-year survival rate of groups A and B were 47.06% and 38.09%,respectively;and there was no statistical significance.The main side-effects of both groups were bone marrow suppression and gastrointestinal reactions,but no statistical difference was observed.Two groups of patients＆#39;quality of life were improved without statistical difference （P 〉 0.05）.Conclusions Body-gamma knife therapy combined with recombinant human endostatin in elderly advanced non-small cell lung cancer patients has better efficacy such as CR rate and long-term survival,and similar side-effects.

关 键 词：放射外科手术 内皮抑素类/治疗应用 癌 非小细胞肺/治疗 

分 类 号：R734.2[医药卫生—肿瘤]