鸦胆子油乳联合顺铂治疗肝癌腹水的疗效观察  

Clinical study in treatment of liver cancer Malignant hydroperitoneum with Brucea Javanica Oil Emulsion injection cisplatin

作　　者：附舰[1] 闵婕[1] 康艳霞[1] 单宇鹏[1] 张峰[1] 张婕[1] 张贺龙[1] 

机构地区：[1]第四军医大学唐都医院肿瘤科,西安710038

出　　处：《陕西中医》2016年第2期131-133,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金资助项目(81101819)

摘　　要：目的:评价鸦胆子油乳联合顺铂治疗肝癌恶性腹腔积液的疗效。方法:对92例符合入选标准的患者进行随机分组、平行对照研究。A组(治疗组,鸦胆子油乳联合顺铂组,腹腔热灌注术循环时腹腔注入顺铂40mg,术毕给予腹腔注入鸦胆子油乳注射液30mL)46例,B组(对照组,腹腔热灌注术循环时腹腔注入顺铂40mg)46例,1次/隔日,连续3次为1个周期,连续做2个周期。观察评价治疗前后临床有效率、生活质量改善、不良反应发生率。结果:与单用顺铂(B组)相比,鸦胆子油乳联合顺铂组(A组),在临床有效率(86.96%,P<0.01)、生活质量改善(52.17%,P<0.01)方面更优,其差异均有统计学意义。结论:鸦胆子油乳联合顺铂腹腔热灌注治疗肝癌恶性腹腔积液可提高临床有效率,并改善患者生活质量。Objective：Evaluation of Brucea Javanica Oil Emulsion with Cisplatin（DDP）efficacy for the treatment of liver cancer Malignant hydroperitoneum.Methods：Ninety-two patients with liver cancer Malignant hydroperitoneum were equally randomized into combination group A（Brucea Javanica Oil Emulsion combined with DDP）and group B（DDP group）.The combination group A was performed intrapleural injection of Brucea Javanica Oil Emulsion30 mL,and DDP 40 mg.The control group B was only given DDP 40 mg,once every other day,three consecutive times,3times for a cycle,for two consecutive cycles.The efficacy,quality of life（QOL）,safety and adverse eventswere evaluated.Results：The recovery rate（RR）of the A group was 86.96%,B group was 52.17%（P〈0.01）.The differences were statistically significant.Conclusion：Intrapleural injection of Brucea Javanica Oil Emulsion combined with DDP is a safe and feasible way to treat with liver cancer Malignant hydroperitoneum.

关 键 词：肝肿瘤 腹水/中西医结合疗法 顺铂/治疗应用 鸦胆子/治疗应用 

分 类 号：R735.7[医药卫生—肿瘤]