艾塞那肽与甘精胰岛素治疗血糖控制不佳2型糖尿病的临床对照研究  

Controlled clinical study of the effect of exenatide and insulin glargine for poor glycemic control in type 2 diabetes

作　　者：简强[1] 李德东[2] 李鹏飞[3] 

机构地区：[1]海军总医院药剂科,北京100048 [2]解放军总医院医保部,北京100039 [3]解放军313医院药剂科,辽宁葫芦岛125000

出　　处：《中国医刊》2016年第2期46-49,共4页Chinese Journal of Medicine

摘　　要：目的探讨艾塞那肽与甘精胰岛素治疗血糖控制不佳2型糖尿病的临床对照效果。方法选取海军总医院收治的血糖控制不佳2型糖尿病患者92例,按照随机数字表法分为艾塞那肽组和甘精胰岛素组各46例,比较两组患者的各项指标。结果两组患者的临床疗效比较,差异无显著性(P>0.05)。两组患者治疗前的体重指数差异均无显著性(P>0.05)。但治疗后艾塞那肽组体重指数较甘精胰岛素组明显降低(P<0.05)。两组患者治疗后的血糖控制情况均较治疗前有明显好转(P<0.05);甘精胰岛素组的空腹血糖控制水平明显优于艾塞那肽组(P<0.05);艾塞那肽组的餐后2小时血糖、糖化血红蛋白控制水平明显优于甘精胰岛素组(P<0.05);两组患者不良反应发生率比较,差异无显著性(P>0.05)。结论相对甘精胰岛素而言,艾塞那肽能更有效地降低患者体重指数,降低糖化血红蛋白和低血糖发生率,值得临床应用。Objective To investigate the effect of exenatide and insulin glargine for poorly glycemic controlled in type 2 diabetes. Method 92 poor glycemic control patients with type 2 diabetes in the navy general hospital were chosen and divided into exenatide group and insulin glargine group, that each group has 46 cases. The clinical efficiency of the two groups were observed and compared, the changes of the body mass index, glycemic control, and the incidence of associated complications. Result The difference of the clinical curative effect between two groups was not statistically significant（P〉0.05）. Compared two groups＇ respective change of their body mass index between before and after treatment, there was no significant difference （P〉0.05）; the body mass index of exenatide group was lower than the insulin glargine after treatment （P〈0.05）. Glycemic control of two groups after treatment was greater than before treatment （P〈0.05）; the control of fasting plasma glucose of ins-ulin glargine group was better than exenatide group （P〈0.05）; the control of 2 hour plasma glucose and hemoglobin Alc of exenatide group was greater than the insulin glargine group （P〈0.05）. Compare the adverse reactions incidence of two groups of patients, there was no significant difference （P〉0.05）. Conclusion Relative to insulin glargine, exenatide can more effectively reduce body mass index, lower glycated hemoglobin, lower incidence of hypoglycemia, which is worth promoting in clinical practice.

关 键 词：艾塞那肽 甘精胰岛素 血糖控制不佳 2型糖尿病 

分 类 号：R781.64[医药卫生—口腔医学]