β-淀粉样蛋白相关性中枢神经系统血管炎  

Amyloidβ-related central nervous system vasculitis

作　　者：李卓[1] 朴月善[1] 卢德宏[1] 

机构地区：[1]首都医科大学宣武医院病理科,北京100053

出　　处：《中国现代神经疾病杂志》2016年第1期3-7,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

摘　　要：淀粉样脑血管病相关性中枢神经系统血管炎亦称为β-淀粉样蛋白(Aβ)相关性中枢神经系统血管炎,主要表现为存在Aβ沉积的小血管壁或其周围慢性炎症性改变。考虑部分患者临床表现、脑脊液和影像学表现不典型,明确诊断仍需依靠脑组织活检。本文拟就其发病机制、病理学特征、临床表现、治疗及预后等进展进行概述。Amyloid β（Aβ）-related central nervous system（CNS） vasculitis, which is also known ascerebral amyloid angiopathy（CAA）- related CNS vasculitis, is characterized by the presence of chronicinflammation within or around the walls of Aβ-deposit blood vessels. Cerebral biopsy is the gold standardfor diagnosis of Aβ- related CNS vasculitis considering the atypical clinical features, cerebrospinal fluid（CSF） and neuroimaging findings of some patients. This paper reviewed the pathogenesis, neuropathology,clinical features, treatment and prognosis of Aβ-related CNS vasculitis.

关 键 词：淀粉样Β蛋白 血管炎 中枢神经系统 病理学 综述 

分 类 号：R743[医药卫生—神经病学与精神病学]