鼻咽癌患者血清胸苷激酶-1水平及其临床意义  

Level of serum thymidine kinase 1 and its clinical implication in patients with nasopharyngeal carcinoma

作　　者：洪俊强 涂德军 张启龙 杨青艳 郭裕林 李彦 曹鸿挺[2] 

机构地区：[1]解放军第一八八医院肿瘤科,广东潮州521000 [2]解放军第四二一医院检验科,广东广州510318

出　　处：《临床军医杂志》2016年第1期44-48,共5页Clinical Journal of Medical Officers

摘　　要：目的探讨鼻咽癌(NPC)患者血清中胸苷激酶-1(TK-1)水平及其临床意义。方法纳入初治NPC患者80例为NPC组,同时设置慢性鼻咽炎组(n=38)及健康对照组(n=32)。收集患者临床资料,治疗前检测TK-1水平及EBV DNA载量,治疗后6个月检测TK-1水平,并定期随访肿瘤复发及转移情况,记录总体生存率。结果 NPC组患者TK-1水平较其他两组高(P<0.01)。不同临床分期患者TK-1由高到低依次为Ⅳ、Ⅲ、Ⅱ、Ⅰ期。NPC患者的TK-1与EBV DNA(r=0.579,P<0.01)及临床分期(rs=0.629,P<0.01)均呈正相关。NPC患者治疗6个月后TK-1显著下降,初始TK-1较高,NPC患者总体生存率更低。结论 NPC患者血清TK-1显著升高,与临床分期及EBV DNA载量一致。初始高TK-1水平提示预后较差。Objective To investigate the level of thymidine kinase 1（ TK-1） and its clinical implication in patients with nasopharyngeal carcinoma（ NPC）. Methods Our research included 80 NPC patients,while matched chronic nasopharyngitis patients（ n = 38）and healthy controls（ n = 32）. We recorded general situation,clinical manifestations and detected serum TK-1 level and EBV DNA load. The level of TK-1 was detected after six months treatment. All Patients with treatment were followed up regularly and the overall survival rate was recorded. Results TK-1 level in NPC patients was higher than chronic nasopharyngitis（ P〈0. 01）. Clinical stage whose the TK-1 levels were from high to low were Ⅳ,Ⅲ,Ⅱ and Ⅰ stage. TK-1 level was correlated with EBV DNA（ r = 0. 579,P〈0. 01） and clinical stage（ rs= 0. 629,P〈0. 01）,respectively. TK-1 level in NPC patients reduced significant after 6 months,and the overall survival rate of NPC patiens with initial higher TK-1 level was lower than others. Conclusion Serum TK-1 level in NPC patients rised significantly,consistent with clinical staging and EBV DNA load. The initial high TK-1 level indicates poor prognosis of the NPC patient.

关 键 词：鼻咽肿瘤 胸苷激酶-1 EB病毒 预后 

分 类 号：R739.62[医药卫生—肿瘤]