30例早期鼻腔NK/T细胞淋巴瘤的生物学特性  

Biological characteristics of the early stage nasal NK/ T cell lymphoma in 30 cases

作　　者：蒋朝阳[1] 王岩松[1] 张伶[1] 潘兴国[1] 咸婧[1] 

机构地区：[1]成都军区总医院肿瘤诊治中心放疗科,四川成都610083

出　　处：《现代肿瘤医学》2016年第6期961-964,共4页Journal of Modern Oncology

摘　　要：目的:回顾性分析30例早期鼻腔NK/T细胞淋巴瘤的生物学行为特点,为临床放疗靶区的设计提供参考。方法:收集2005年3月至2013年9月间收治的30例经病理证实为早期原发于鼻腔的NK/T细胞淋巴瘤患者的资料,根据Ann Arbor分期标准,所有患者均为IE/IIE期且都有影像检查资料可查,并以影像学为标准分析邻近受侵器官和结构的数目,同时分析颈部淋巴结的转移情况。结果:鼻腔周围结构受侵患者占所有患者的比例为76.7%(23/30),其具体受侵如下:上颌窦为36.6%、筛窦与鼻咽同为30%、鼻翼为20%、翼突与蝶窦同为10%,翼腭窝及额窦、硬腭、眼眶、口咽同为3.3%;头颈部淋巴结转移的患者占所有患者的比例为46.7%(14/30),其具体转移如下:I区与II区同为26.7%,III区为10%,VIIa为6.7%,IV区与IX同为3.3%。结论:在早期鼻腔NK/T细胞淋巴瘤放射治疗时,其靶区的勾画应该考虑受侵和转移几率均较高的结构和区域。Objective： Retrospective analyzed the biological characteristics of the early stage nasal NK/T cell lymphoma in 30 cases and provide a reference for the contour of clinical radiotherapy target region. Methods： Thirty patients with pathologically confirmed nasal NK / T cell lymphoma from March 2005 to September 2013 were analyzed.All patients were stage as IE / IIE according to Ann Arbor criteria with imaging data available. Using imaging as standard to analyzed the adjacent organs and structures that were infiltrated,also metastasis of cervical lymph nodes. Results： The proportion of the infiltrated structures around the nasal cavity was 76. 7%（ 23 /30） of all patients. The infiltrated structures were as follows： maxillary sinus（ 36. 6%）,ethmoid sinus（ 30%）,nasopharynx（ 30%）,nasal ala（ 20%）,pterygoid process（ 10%）,sphenoidal sinus（ 10%）,pterygopalatine fossa and frontal sinus,hard palate,orbit,oropharynx were 3. 3% respectively. The proportion of cervical lymph nodes metastasis was 46. 7%（ 14 /30） of all patients： Ⅰ（ 26. 7%）,Ⅱ（ 26. 7%）,Ⅲ（ 10%）,Ⅶa（ 6. 7%）,Ⅳand Ⅸwere 3. 3% respectively. Conclusion： The infiltrated structures and regions with high rate should be considered during the radiotherapy of early stage nasal NK /T cell lymphoma.

关 键 词：鼻腔 NK/T细胞淋巴瘤 生物学特性 

分 类 号：R733.1[医药卫生—肿瘤]