染色质解旋酶DNA结合蛋白与肿瘤关系的研究进展  

Progress in the relationship between chromatin helicase DNA binding protein and tumor

作　　者：王雪[1] 杨连赫[1] 于建发 沈帅[1] 于承仟 兰琦[1] 李政晔 

机构地区：[1]中国医科大学,辽宁沈阳110000

出　　处：《现代肿瘤医学》2016年第6期992-995,共4页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81301930);辽宁省教育厅科学研究一般项目(编号:L2015595)

摘　　要：染色质解旋酶DNA结合蛋白5(CHD5)属于染色质重塑酶,其既能重塑染色质促进基因转录,又能正向调控p53/p19arf控制细胞增殖、凋亡和衰老。目前,已经在神经母细胞瘤、胶质瘤、乳腺癌、肺癌等多种肿瘤中发现CHD5的缺失并发现其低表达与肿瘤的发生、发展、预后情况有关。在多种肿瘤中,CHD5基因出现单链或双链缺失,以及高甲基化现象,导致其表达下调。可见,CHD5通过遗传学和表观遗传学机制共同控制肿瘤进展,在肿瘤的发生发展中发挥重要作用。Chromatin helicase DNA binding protein 5（ CHD5） belongs to chromatin remodeling enzymes,which can not only promote gene transcription because of chromatin remodeling,but also upregulate p53 / p19 arf when controlling cell proliferation,apoptosis and senescence. At present,CHD5 missing has been found in various kinds of tumors like neuroblastoma,glioma,breast cancer and lung cancer and scientists also find that the low expression is related to tumor occurrence,development and prognosis. In a variety of tumors,CHD5 gene deletion occurs single or double stranded,as well as hypermethylation,leading to down regulation. Hence,CHD5 plays an important role in the development of tumor both by genetic and epigenetic mechanisms of joint control in tumor progression.

关 键 词：CHD5 甲基化 肿瘤 抑癌基因 

分 类 号：R730[医药卫生—肿瘤]