高血压合并AMI患者中ALD、NT-proBNP、cTnI的临床意义  

Clinical significance of c Tn I, NT-pro BNP and ALD in hypertension combined with AMI

作　　者：谷秀娟[1] 钱晓蓉[2] 高枫[2] 阮彩莲[2] 王晨霞[1] 邢延芳[1] 

机构地区：[1]延安大学附属医院检验科,陕西延安716000 [2]延安大学医学院实验中心,陕西延安716000

出　　处：《中国医药导报》2016年第5期59-62,共4页China Medical Herald

基　　金：陕西省延安市科学技术研究发展计划项目(2014HM-07)

摘　　要：目的探讨醛固酮（ALD）、氮末端脑钠肽前体（NT-proBNP）、心肌肌钙蛋白（cTnI）联合检测在高血压合并急性心肌梗死（AMI）中的临床意义。方法选取2014年12月~2015年4月在延安大学附属医院既往有高血压病史的AMI患者60例作为观察组,健康体检的中老年人45例作为对照组,进行ALD、NT-proBNP、cTnI定量检测分析。ALD采用化学发光分析法,NT-proBNP采用电化学发光分析法,cTnI采用快速免疫荧光分析法,并进行统计学分析。结果观察组ALD、NT-proBNP和cTnI浓度分别为（256.0±60.9）、（1920±689.08）ng/L和（5.32±1.52）μg/L明显高于对照组,差异有统计学意义（P〈0.05）;ALD、NT-proBNP和cTnI单项指标检测的阳性率分别为68.30%、80.00%、70.00%,明显高于对照组,差异有统计学意义（P〈0.05）;观察组ALD、NT-proBNP和cTnI联合检测的真阳性率最高（98.33%）。结论检测血清ALD、NT-proBNP、cTnI浓度,为临床筛查高血压合并AMI患者提供有价值的实验室依据。Objective To investigate the effects of aldosterone（ALD）, n-terminal brain natriuretic peptide precursor（NT-proBNP）, myocardial troponin joint detection（cTnI） in hypertension complicating acute myocardial infarction（AMI） clinical significance. Methods 60 patients of a history of high blood pressure with AMI in Yan ＇an University Affiliated Hospital from December 2014 to April 2015 were selected as observation group, 45 cases of medical health middle aged and elderly people as control group. ALD, NT-proBNP and cTnI were performed quantitative detection analysis. ALD was performed chemiluminescence analysis, NT-proBNP was performed electrochemical luminescence analysis, cTnI was performed fluorescence analysis, and statistical analysis was used. Results ALD, NT-proBNP and cTnI concentration of observation group was（256 ±60.9）,（1920 ±689.08）ng/L and（5.32 ±1.52）μg/L respectively, which were significantly higher than those of control group, the difference was statistically significant（P〈0.05）; ALD, NTproBNP and cTnI single parameter test positive rate was 68.30%, 80.00%, 70.00% respectively, which were significantly higher than those of control group, the difference was statistically significant（P〈0.05）; ALD, NT-proBNP and cTnI joint detection of true positive rate of observation group is the highest（98.33%）. Conclusion Detection of serum concentration of ALD, NT-proBNP and cTnI provide valuable laboratory basis.for clinical screening for hypertension combined AMI patients.

关 键 词：醛固酮 氮末端脑钠肽前体 心肌肌钙蛋白 高血压 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病] R544.1[医药卫生—内科学]