Argonaute2蛋白在多发性骨髓瘤骨髓组织中的表达及与微血管密度的关系  

Argonaute2 expression and its correlation with microvessel density in multiple myeloma

作　　者：纪贤良 梁敏燕 王艳丽[1] 赵英哲[1] 刘柳[1] 

机构地区：[1]阜新市中心医院血液肿瘤科,辽宁阜新123099 [2]梧州市中医医院药剂科

出　　处：《临床血液学杂志》2016年第1期48-50,54,共4页Journal of Clinical Hematology

摘　　要：目的：研究Argonaute2（Ago2）在多发性骨髓瘤（MM）骨髓组织中的表达情况及其与微血管密度（MVD）的关系。方法：应用EnVison免疫组织化学法检测53例MM骨髓组织和21例正常骨髓组织中Ago2蛋白表达水平及MVD计数。结果：1MM骨髓组织Ago2蛋白阳性表达率为88.7%,对照组织中未发现Ago2蛋白表达,2组差异有统计学意义（P〈0.01）;2 MM骨髓组织中MVD为42.44±6.82,对照组织中MVD为7.23±4.18,2组差异有统计学意义（P〈0.01）;3在MM骨髓组织中,Ago2表达阳性患者骨髓组织中的MVD计数显著高于Ago2阴性表达患者（P〈0.05）,并且经Spearman相关性分析发现Ago2表达水平与MVD具有显著的正相关关系（r=0.521,P=0.011）。结论：Ago2蛋白在MM骨髓组织中的表达显著上调,并对骨髓中的血管生成具有一定调节作用。Objective：To investigate the expression of Argonaute2（Ago2）protein in multiple myeloma（MM）and its correlation with microvessel density（MVD）.Method：The expression of Ago2 protein and CD34 in 53MM tissues and 21 normal controller tissues were measured by EnVison immunohistochemistry.Result：1No marked expression of Ago2 was observed in the normal tissues,which was lower than 88.7%in MM tissues（P〈0.01）.2The mean MVD value of the normal tissues was 7.23±4.18,which was lower than 42.44±6.82 in MM tissues（P〈0.01）.3In MM tissues,the mean MVD value of Ago2 positive cases was significantly higher than that of Ago2 negative cases（P〈0.05）,and there was a positive correlation between the expression of Ago2 and MVD（r=0.521,P=0.011）.Conclusion：Ago2protein is up-regulated in bone marrow biopsies of MM,and it may regulate the angiogenesis of bone marrow.

关 键 词：多发性骨髓瘤 Argonaute2 微血管密度 免疫组织化学 

分 类 号：R733.3[医药卫生—肿瘤]