我国慢性粒细胞白血病研究现状的共词分析  

A co-word analysis of current research on chronic myeloid leukemia in China

作　　者：景晓宇[1] 鲍珊[1] 董天[1] 刘霆[1] 

机构地区：[1]四川大学华西医院血液内科,成都610041

出　　处：《临床血液学杂志》2016年第1期51-54,共4页Journal of Clinical Hematology

摘　　要：目的:以共词分析的方法,对我国近年来慢性粒细胞白血病的研究进展进行探讨,分析、总结我国现阶段该领域的研究热点和趋势。方法:将"慢性粒细胞白血病"、"慢性髓细胞白血病"作为关键词,限定期刊年限为2012-01-2015-01,在中国知网(CNKI)上进行检索。将关键词导入Excel 2013进行统计与分析,之后利用Ucinet 6.0及Netdraw描绘共现分析图,并展现高频关键词之间的共篇关系。结果:通过本研究制定的纳入排除标准对文献进行筛选,最终将符合标准的371篇文章纳入研究,提取高频关键词29个(T≥6),展现我国目前慢性粒细胞白血病的研究热点及趋势,通过描绘共现分析图,展现各高频关键词之间的相互联系。结论:现阶段我国慢性粒细胞白血病在发病机制、酪氨酸激酶抑制剂的耐药、治疗方案的优化选择等方面取得了较多新的研究成果,在未来,探讨药物治愈慢性粒细胞白血病的可能性、进行慢性粒细胞白血病的分层治疗及疾病社区管理将成为新的研究热点。Objective：To study the current situation of chronic myeloid leukemia（CML）research in recent years by co-word analysis,and to discuss and summarize the hotspot and trend of CML research in China.Method：We used ＂chronic myeloid leukemia＂ as key word to search for relevant data from January 2012 to January 2015 in CNKI.Then we selected out the appropriate papers according to strict inclusion and exclusion criteria and extracted high-frequency key words.With Ucinet 6.0and Netdraw,we showed the relationships among the high-frequencykey words which had been statistical analyzed by Excel 2013.Result：A total of 371 appropriate papers were included in this research and 29high-frequency key words were extracted.The relationships among the high-frequency key words and the research hotspot and trend about CML are revealed.Conclusion：There are many new achievements about CML in etiology,TKI tolerance and the optimal therapeutic schedule in each period.In the future,the possibility to cure CML by drugs,stratification treatment and community management of CML will be a new hotspot.

关 键 词：白血病 粒细胞 慢性 BCR-ABL融合基因 酪氨酸激酶抑制剂 耐药 

分 类 号：R733.72[医药卫生—肿瘤]