脑苷肌肽辅助治疗老年脑梗死的研究  

Clinical investigation of the efficacy about cattle encephalon glycoside and ignotin in the treatment of elderly patients with cerebral infarction

作　　者：魏守蓉[1] 王丽平[1] 陈敏[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院,湖北武汉430077

出　　处：《现代中西医结合杂志》2016年第7期702-704,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：2014年湖北省科技计划项目(2014CFB957)

摘　　要：目的探讨脑苷肌肽辅助治疗老年脑梗死患者的临床疗效及其作用机制。方法将100例老年脑梗死患者随机分为观察组与对照组各50例。2组均给予常规基础治疗,丁苯酞氯化钠注射液静脉滴注,观察组在此基础上给予脑苷肌肽注射液静滴,2组疗程均为14 d。检测2组治疗前和治疗14 d后血清S-100蛋白(S100B)、神经肽Y(NPY)、同型半胱氨酸(Hcy)、IL-6、P选择素、TNF-ɑ及血浆血管性血友病因子(v WF)水平;统计2组治疗前和治疗14 d后神经功能缺损程度评分,比较2组临床疗效。结果 2组治疗后血清S100B、NPY、Hcy、IL-6、P选择素、TNF-ɑ及血浆v WF水平均较治疗前明显降低(P均<0.05),且观察组明显低于对照组(P均<0.05)。2组治疗后NIHSS评分均明显低于治疗前(P均<0.05),且观察组明显低于对照组(P<0.05)。观察组总有效率明显高于对照组(P<0.05)。结论常规治疗同时辅助应用脑苷肌肽可显著降低老年脑梗死患者血清S100B、NPY、Hcy、IL-6、P选择素、TNF-ɑ及血浆v WF水平,提高治疗有效率,促进神经功能恢复,临床疗效肯定。Objective It is to investigate efficacy and mechanism about cattle encephalon glycoside and ignotin in the treatment of elderly patients with cerebral infarction. Methods A total of 100 cerebral infarction patients were randomly divided into the observation group（ 50 cases） and the control group（ 50 cases）. Both the groups were given normal basic therapy,and Butylphthalide-Sodium Chloride Injection,the observation group was added with cattle encephalon glycoside and ignotin,both the treatment courses were 14 days. The serum levels of S100 B,NPY,Hcy IL- 6,P selectin,TNF- α,and plasma v WF were determined before treatment and in 14 days after treatment. The harmful degree of nervous function before treatment and in 14 d after treatment were evaluated and clinical efficacy were compared in the two groups. Results At 14 d after treatment,the serum levels of S100 B,NPY,Hcy,IL- 6,P selectin,TNF- ɑ,and plasma level of v WF were significantly lower than those before treatment（ P〈0. 05）,and the levels in observation group was significantly lower than those in control group（ P〈0. 05）. After 15 days,the decrease value of NIHSS scores were lower than those before treatment in both groups,and the scores in observation group was less than those in control group. The total effective rate in observation group was higher than that in control group（ P〈0. 05）. Conclusion For the elderly patients with cerebral infarction,routine treatment assisted by cattle encephalon glycoside and ignotin can reduce the serum levels of S100 B,NPY,Hcy IL- 6,P selectin,TNF- α,and plasma v WF,and can enhance the clinical efficacy,degree of nervous function and with definite curative effect.

关 键 词：脑苷肌肽 脑梗死 S-100B蛋白 同型半胱氨酸 神经肽Y 

分 类 号：R743.33[医药卫生—神经病学与精神病学]