益气活血方分子作用于心肌缺血疾病靶点的网络药理学研究  

Study on network pharmacology of molecules in Yiqi Huoxue Formula on disease targets of myocardial ischemia

作　　者：吴佳妮[1] 郭书文[1] 陈曦[1] 张璐[1] 武建功[1] 刘文臣[1] 苏兆铎 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2016年第2期467-471,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81473552)~~

摘　　要：目的:对益气活血方黄芪、当归、人参、三七、川芎5味中药进行网络药理学的研究,探索其治疗心肌缺血的活性成分,进一步阐明其药效物质基础,为该方药后期推广提供研究支持。方法:采用分子对接和网络分析方法快速筛选益气活血方中治疗心肌缺血的活性成分,研究益气活血方所含分子治疗心肌缺血的网络药理学性质。结果:若将网络度设为大于8时,20个化合物与20个心肌缺血靶标之间的介数和网络度较高,分析显示益气活血方主要通过此20个有效成分协同作用来发挥治疗效果。结论:网络药理学的研究方法有助于分析益气活血方中可能的活性分子,并通过作用于相关靶点治疗心肌缺血疾病。Objective：To conduct computing network pharmacological studies on Radix Astragali seu Hedysari,Radix Angelicae Sinensis,Radix Ginseng,Radix Notoginseng and Rhizoma Ligustici Chuanxiong of Yiqi Huoxue Formula,in order to explore the active constituents in the treatment of myocardial ischemia,clarify the effective constituents of this formula in treating myocardial ischemia,in order to provide a research support for clarifying the pharmacodynamic material basis and popularizing of this formula in future.Methods：Molecular docking and network analysis methods were applied to screen the active constituents of Yiqi Huoxue Formula in treating myocardial ischemia,in order to study the network pharmacological properties of molecules included in Yiqi Huoxue Formula in treating myocardial ischemia.Results：If the network degree was greater than 8,the betweenness and network degree between 20 compounds and 20 anti-myocardial ischemia targets were relatively high.Analysis results showed that Yiqi Huoxue Formula played a role in treating myocardial ischemia based on synergistic effect among the 20 effective constituents.Conclusion：Network pharmacology methods contributed to analyze the possible active molecules in Yiqi Huoxue Formula,which could treat myocardial ischemia disease by acting on the related targets.

关 键 词：益气活血方 分子对接 心肌缺血 网络药理学 

分 类 号：R285[医药卫生—中药学]