DMO用于大鼠麻醉效果的观察  

The effect of DMO for anesthesia observed in rats

作　　者：时静[1] 刘海玉[1] 白鸽[1] 姜胜[1] 贾烁 付礼胜 刘思浩 范宏刚[1] 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030

出　　处：《中国兽医杂志》2016年第1期113-116,共4页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金项目(31001092);黑龙江省普通高等学校重点实验室开放课题资助项目(yy-2012-11;mz-2012-10);东北农业大学大学生创新创业训练计划项目(2013026)

摘　　要：针对国内外没有大鼠专用的复合麻醉剂,本研究将右旋美托咪啶、咪达唑仑、强痛定和阿托品配成复合制剂（DMO）经腹腔给药麻醉大鼠,观察其对大鼠的镇静、镇痛、肌松等效果及对主要生理机能的影响.结果显示,注射DMO后,心率呈先降低后上升的趋势,与0 min相比变化范围在11.11％～16.67％;平均动脉压呈先升高后降低的趋势,20～30 min维持高血压状态,在其生理耐受范围内.DMO诱导迅速,维持时间适宜,苏醒后可迅速恢复;镇痛、镇静、肌松效果良好.Since there is no specific composite anesthetic for rats in the world, this study will investigate the effects of DMO in- cluding dexmedetomidine, midazolam, bucinnazine and atropine by intraperitoneal administration on the sedation, analgesia, mus- cle relaxants and the impacts on major physiological functions for anesthetized rats. The results showed that ： after injection with DMO, heart rate exhibited an upward trend after the decline compared with that at 0 min, and varied from 11.11% -16.67% ; mean arterial pressure increased first and then decreased, maintaining blood pressure state at 20-30 min, which is within their physiological tolerance. DMO induced rapid, appropriate duration, and the rats can be quickly restored after awakening. Also, anal- gesic, sedative, and muscle relaxant effect is good.

关 键 词：大鼠 麻醉 效果观察 

分 类 号：R-332[医药卫生]