MUC15和PI3K/Akt表达与胃癌临床病理特征及预后的相关性研究  

Expression of MUC15 and PI3K/Akt in gastric carcinoma and its association with clinicopathological characteristics and prognosis

作　　者：韩志伟[1] 戎瑞洲 孔鹏洲[2,3] 程彩霞[4] 张燕燕[1] 董金垚[1] 李曙晶[1] 郭建昇[1] 

机构地区：[1]山西医科大学第一医院普通外科,太原市030001 [2]山西医科大学转化医学研究中心 [3]山西医科大学细胞生理学教育部重点实验室 [4]山西医科大学第一医院病理科

出　　处：《中国肿瘤临床》2016年第2期56-61,共6页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨MUC15和PI3K/Akt的表达与胃癌临床病理特征和预后的关系。方法:采用组织芯片和免疫组织化学法检测144例胃癌组织及对应癌旁组织中MUC15、Akt的表达。结果:MUC15在胃癌中阳性表达率为79.8%,高于癌旁组织中的阳性表达率22.2%(P<0.01);Akt在胃癌中阳性表达率为80.6%,高于癌旁组织的阳性表达率16.7%(P<0.01)。MUC15和Akt表达均与胃癌分化程度、浸润深度、有无淋巴结转移和TNM分期相关(P<0.05);且胃癌组织中MUC15表达和Akt表达呈正相关(P=0.001)。单因素生存分析显示,MUC15和Akt高表达均与生存时间呈负相关(P<0.05)。Cox多元回归分析提示,MUC15和Akt同时阳性的胃癌患者预后更差(HR=3.115,P<0.05)。结论:MUC15可能通过PI3K/Akt细胞信号转导通路参与胃癌的发生、发展、浸润转移,MUC15结合Akt是胃癌预后强有力的预测因子。Objective：To analyze the expression of MUC 15and PI 3K/Akt in gastric carcinoma and its association with clinicopathologi-cal characteristics and prognosis. Methods：The expression of MUC 15and Akt was detected in 144 cases of gastric carcinoma tissues and corresponding para- carcinoma tissues by tissue microarray and immunohistochemistry.Results： The positive expression rate of MUC15in gastric carcinoma was 79. 8%, higher than that of para-carcinoma tissues （22. 2%, P〈0. 01）. The positive expression rate of Akt protein in gastric carcinoma was80. 6%, higher than that of para-carcinoma tissues （16. 7%, P〈0. 01）. The expression of MUC15and Akt was statistically associated with the grades of differentiation, invasion depth, lymphatic metastasis, TNM stage of tumor tissues （ P〈0. 05）, and the positive correlation between the two protein expression that appear in the gastric tumor tissue （ P=0. 001 ）. Univariate survival analysis showed that the over-expression of either MUC 15or Akt was inversely correlated with the survival time （P〈0. 05and P〈0. 01, respectively）. Cox multiple regression analysis indicated that patients with over- expression of both MUC 15and Akt had the worst prognoses （HR=3. 115 , P〈0. 05）. Conclusion： MUC15may be involved in the occurrence, development, invasion, and metastasis of gastric cancer through the PI 3K/Akt cell signaling pathway, and the expression of MUC 15combined with Akt is a powerful predictor for the prognosis of gastric cancer.

关 键 词：胃癌 免疫组织化学 MUC15 PI3K/AKT 预后 

分 类 号：R735.2[医药卫生—肿瘤]