4-Dimethylaminopyridine-catalyzed Cascade Reaction for Efficient Synthesis of Naphthofurans  

作　　者：FAN Chenli HE Xinwei LIAO Kaisheng WANG Cui'e SHANG Yongjia 

机构地区：[1]Department of Material Engineering, Wuhu Institute of Technology, Wuhu 241003, P. R. China [2]Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, P. R. China

出　　处：《Chemical Research in Chinese Universities》2016年第1期62-67,共6页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（Nos.21172001, 21372008）, the Program for the New Century Excellent Talents in University of China（No.NCET-10-0004） and the Natural Science Foundation of Anhui Province of China（No. 1308085QB39）.

摘　　要：A convenient and efficient method was developed for the synthesis of naphtho[2,1-blfurans via 4-dimethylaminopyridine（DMAP）-catalyzed cascade reaction of 2-hydroxy-l-naphthaldehydes and a-halogenated ketones in moderate to good yields in the presence of Na2CO3 at 80 ~C for 6 h. The mechanism for this process was briefly discussed with a tentative catalytic cycle proposed. Moreover, this method features organocatalysts and high step-economy, which makes it practical and attractive.A convenient and efficient method was developed for the synthesis of naphtho[2,1-blfurans via 4-dimethylaminopyridine（DMAP）-catalyzed cascade reaction of 2-hydroxy-l-naphthaldehydes and a-halogenated ketones in moderate to good yields in the presence of Na2CO3 at 80 ~C for 6 h. The mechanism for this process was briefly discussed with a tentative catalytic cycle proposed. Moreover, this method features organocatalysts and high step-economy, which makes it practical and attractive.

关 键 词：4-DIMETHYLAMINOPYRIDINE a-Halogenated ketone Cascade reaction Naphthofuran ORGANOCATALYSIS 

分 类 号：TQ028.8[化学工程] TN915.05[电子电信—通信与信息系统]