蛋白酪氨酸磷酸酶受体D（PTPRD）在食管鳞状细胞癌组织中的表达及其临床意义  

Expression and Clinical Relations of PTPRD in Esophageal Squamous Cell Carcinoma

作　　者：李陕区[1] 兰淼[2] 赵仁礼 杨博[1] 巩丽[2] 韩秀娟[2] 姚丽[2] 朱少君[2] 张伟[2] 

机构地区：[1]第四军医大学唐都医院门诊部,西安710038 [2]第四军医大学唐都医院病理科,西安710038 [3]第四军医大学学员旅,西安710032

出　　处：《现代检验医学杂志》2016年第1期1-4,共4页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金资助项目（No.81001088;No.81372226）陕西省社发攻关项目（2012K13-01-15）,国家高新技术研究发展计划（973）重点项目（No.2009CB521704）.

摘　　要：目的探讨蛋白酪氨酸磷酸酶受体（PTPRD）基因表达与食管鳞状细胞癌（ESCC）患者临床病理特征及预后的关系。方法应用免疫组织化学SP染色法分析236例ESCC标本中PTPRD基因产物表达情况和定位，收集所有患者的临床病理资料并进行了术后5年随访用于统计分析。结果统计分析显示PTPRD在ESCC组织中的表达明显低于在正常食管鳞状上皮中的表达（22．0％VS57．2％，P=0．000）。而且PTPRD的表达与分化程度、浸润深度和有淋巴结转移有关。PTPRD的表达强度在分化好的组高于分化差的组（P=0．013），在浸润浅的组高于浸润深的组（P=0．025），在无淋巴结转移组高于有淋巴结转移组（P=0．019）。PTPRD的表达强度与性别、年龄无关（P=0．170，0．787）。随访资料生存分析显示PTPRD表达强的患者预后较好。结论PTPRD与ESCC的发生发展和预后密切相关，可能是ESCC发生相关的新的潜在的抑癌基因，其表达水平可作为估计临床预后的一个可能参考指标。Objective To identify the expression of PTPRD in esophageal squamous cell carcinoma （ESCC） and analyze its correlation with pathological features and patient survival. Methods Immunohistochemistry analysis was applied to detect the expression level and location of PTPRD in 236 patients with ESCC. Clinical and pathological features were collected and a 5 years＇ follow-up after surgery were performed. Results Statistic analysis showed that expression of PTPRD in ESCC was lower than in normal esophageal epithelial cells （22.0% vs 57.2% ,P=0. 000）. The expression of PTPRD was correlated to the differentiation grade,depth of tumor invasion and lymph nodes metastasis. The expression of PTPRD was higher in group with well differentiation, less invasion depth and no lymph node metastasis （P = 0. 013,0. 025,0.019）. The expression of PTPRD was not correlated to age or gender （P=0. 170,0. 787）. The survival analysis showed that thegroup with more PTPRD expression had better prognosis. Conclusion PTPRD was correlated to progression and prognosis of ESCC. It may be a new potential tumor suppressor gene of ESCC,and its expression level might may a useful marker for predicting prognosis for ESCC patients.

关 键 词：蛋白酪氨酸磷酸酶受体 食管鳞状细胞癌 免疫组织化学 预后 

分 类 号：R735.1[医药卫生—肿瘤] R730.43[医药卫生—临床医学]