重症肌无力患者外周血中性粒细胞／淋巴细胞比值和血小板／淋巴细胞比值的临床意义  

Clinical Significance of Neutrophiis/Lymphocyte and Platelet/Lymphocyte Ratio of Peripheral Blood in Patients with Myasthenia Gravis

作　　者：刘挺挺[1] 李虎[1] 马炜[1] 陈燕[1] 谷明莉[1] 张蕾[1] 邓安梅[1] 

机构地区：[1]第二军医大学附属长海医院实验诊断科,上海200433

出　　处：《现代检验医学杂志》2016年第1期65-68,共4页Journal of Modern Laboratory Medicine

基　　金：973项目子课题（2013CB531606）;国家自然科学基金（81471605,81302579,81300748,81273282,81202353）;上海申康基金（CHDC22014014）;长海医院基金资助项目（CH125530300）;南京军区医药卫生科研基金（12MA056）;军队科研基金（BWSl4J023）.

摘　　要：目的探讨重症肌无力（MG）患者外周血中性粒细胞／淋巴细胞比值（NLR）和血小板／淋巴细胞比值（PLR）的临床意义。方法选取2013年1月～2014年12月期间长海医院收治的54例MG患者及体检的57名健康成人归为MG组及对照组。比较两组及不同临床分型MG患者的WBC计数、NLR及PLR，通过受试者工作曲线（ROC）曲线下的面积评价各指标对MG的诊断价值。结果MG组的WBC计数、NLR及PLR分别为（6．85±0．37）×10^9／L，2．48±0．19和118．79±6．38，显著高于对照组（5．87±0．12）×10^9／L，1．59±0．06和102．01±3．45（P〈0.05）。WBC计数、NLR及PLR的ROC曲线下面积分别为0．559，0．717和0．58]。Ⅲ或Ⅳ型的PLR显著高于Ⅰ型，Ⅱ型（P〈0．05）。结论MG患者的NLR和PLR均显著升高，NLR的诊断价值更高，PLR可能与疾病严重程度有关。Objective To investigate the clinical significance of neutrophils/lymphocyte ratio （NLR） and platelet/lymphocyte ratio （PLR） of peripheral blood in patients with myasthenia gravis （MG）. Methods 54 patients with MG treating from January 2013 to December 2013 in Changhai hospital and 57 healthy adults who received check-up were enrolled the study as MG group and control group. WBC count,NLR and PLR were compared between two groups and among different clinical classifications in MG patients. The area under the receiver operating characteristic （ROC） curve was performed to evaluate these indicators＇ diagnostic value for MG. Results The WBC count, NLR and PLR in MG group were （6.85±0.37）×10^9/ L,2.48±0.19 and 118.79±6.38 respectively,which were significantly higher than （5.87±0.12）×10^9/L,1.59±0.06 and 102.01±3.45 in control group （P〈0.05）. The area under the ROC curve of WBC count,NLR and PLR were 0, 559,0. 717 and 0. 581 respectively. PLR of MG patients with type Ⅲ or Ⅳ was significantly higher than that of patients with type Ⅰ , Ⅱ （P〈0. 05）. Conclusion NLR and PLR of MG patients increased significantly. The diagnostic value of NLR is higher,and PLR may be associated with the severity of disease.

关 键 词：重症肌无力 中性粒细胞/淋巴细胞比值 血小板/淋巴细胞比值 炎症 

分 类 号：R746.1[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]