药物性肝损伤发病机制的研究进展  

Research advances in the pathogenesis of drug-induced liver injury

作　　者：许新[1,2] 纪莉莎[2] 芦琳琳[3] 陈丽丽[2] 辛永宁[4,5] 宣世英[4,5,6] 

机构地区：[1]大连医科大学,辽宁大连116044 [2]青岛市市立医院内镜中心,青岛266021 [3]青岛市市立医院中心实验室,青岛266021 [4]青岛市市立医院消化内二科,青岛266021 [5]青岛市消化疾病重点实验室,青岛266021 [6]中国海洋大学医药学院,青岛266003

出　　处：《临床肝胆病杂志》2016年第2期382-385,共4页Journal of Clinical Hepatology

基　　金：肝脏疾病临床研究与转换医学技术平台的构建(2012ZX09303-001)

摘　　要：近年来,随着用药种类和不合理用药的日益增多,药物性肝损伤(DILI)发病率及病死率日益增高。DILI发病机制复杂,可能涉及药物的直接肝毒性作用、免疫介导性的肝损伤、线粒体损伤、胆道损伤等方面。探讨及了解其发病机制对预防及治疗DILI尤为重要。综述了DILI发病机制的研究进展。In recent years, with an increasing number of drug types and unreasonable drug use, incidence and mortality of drug - in- duced liver injury （DILI） have been increasing. The pathogenesis of DILI is complex, and may involve liver injury caused by the direct effect of drugs, immune -mediated liver injury, mitochondrial injury, and bile duct injury, etc. This article mvesngates the pathogenesis and its important role in the prevention and treatment of DILI, and reviews the research advances in the pathogenesis of DILI.

关 键 词：肝疾病 综述 

分 类 号：R575[医药卫生—消化系统]