CDX2、survivin在伴鸡皮样改变大肠腺瘤中的表达情况  

Expressions of CDX2 and survivin in colorectal adenoma with chicken-skin mucosa

作　　者：韩丹[1] 关景明[2] 

机构地区：[1]沈阳市第四人民医院,110031 [2]哈尔滨医科大学附属第二医院,150001

出　　处：《国际医药卫生导报》2016年第4期457-459,463,共4页International Medicine and Health Guidance News

摘　　要：目的探讨CDX2、survivin与大肠腺瘤癌变的关系及伴结肠鸡皮样粘膜（CSM）的大肠腺瘤的临床意义。方法采用RT—PCR和免疫组化sP法检测CDX2、survivin在正常大肠粘膜、伴CSM的大肠腺瘤、不伴CSM的大肠腺瘤和大肠腺瘤癌变组织中的表达情况。结果CDX2和survivin的表达在伴CSM的大肠腺瘤与腺瘤癌变组织中比较，差异无统计学意义（P〉0．05）；与不伴CSM的大肠腺瘤和正常大肠粘膜组织比较，差异有统计学意义（P〈0．01）。结论CDX2、Survivin共同参与了大肠腺瘤的癌变过程，伴CSM的大肠腺瘤在一定程度上比不伴CSM的大肠腺瘤易癌变。Objective To explore the relationship of CDX2 and survivin with cancerous adenoma and the clinical significance of colorectal adenoma with chicken-skin mucosa （CSM）. Methods The expressions of CDX2 and survivin in normal colorectal mucosa, colorectal adenoma with CSM, colorectal adenoma without CSM and colorectal adenocarcima were detected by RT-PCR and immunohistochemistry SE Results There were no statistical differences in the expressions of CDX2 and survivin between colorectal adenoma with CSM and colorectal adenocarcima （P〉0.05） but were between colorectal adenoma and normal colorectal tissue （P〈0.01）. Conclusions CDX2 and survivin participate the process of adenoma canceration together. Colorectal adenomas with CSM is more cancerating than that without CSM.

关 键 词：CDX2 SURVIVIN 大肠腺瘤 鸡皮样粘膜 癌变 

分 类 号：R735.7[医药卫生—肿瘤]