短期VLCD干预对超重肥胖患者骨代谢影响的研究  

Effects of a short-term very lowcarbohydrate diet intervention on bone turnover ofoverweight and obese subjects

作　　者：林晨[1] 郑和昕[1] 张微[1] 单晶[1] 赵小红[1] 王霞[1] 

机构地区：[1]浙江医院,浙江杭州310013

出　　处：《浙江医学教育》2016年第1期47-49,57,共4页Zhejiang Medical Education

摘　　要：目的:探讨短期极低碳水化合物饮食(VLCD)干预对超重肥胖患者骨代谢指标的影响。方法:将205例超重或肥胖受试者以1:3比例随机分配至"单纯生活方式干预组"(对照组)和"单纯生活方式加VLCD干预组"(干预组)。比较2种不同干预方式在干预前后体重、体重指数(BMI)、腰围及甲状旁腺素(PTH)、β胶原特殊序列(β-CTx)、总N端骨钙素(TNOC)、I型前胶原氨基端延长肽(P1NP)、25-羟化维生素D3[25-(OH)-D3]的变化。结果:2种不同干预方式在干预后体重、BMI、腰围均较干预前明显下降,但VLCD治疗组在干预后下降较对照组明显(P<0.01)。2组干预前后骨代谢指标变化差异无统计学意义(P>0.05)。结论:短期VLCD护理对超重肥胖患者体重、BMI、腰围明显改善,对骨代谢指标总体无明显影响。[ Objective] To investigate the effects of a short- term very low carbohydrate diet （VLCD） intervention on bone turnover of overweight and obese subjects. [ Method] A total of 205 overweight or obese subjects were recruited and random- ized into control group and treatmeat groupwith a ratio of 1：3. The control group received medical lifestyle intervention, while the intervention group received very low carbohydrate diet intervention in addition to medical lifestyle intervention. Body weight, waist circumstance, BMI, Parathyroid hormone（PTH）, -- crosslaps（β- CTx）, N- terminal osteocalcin （TNOC） , total pro- collagen I type N- terminal propepfide （P1NP） and 25- OH- D3of each subjectwere measuredbefore and after the interven- tmn Result ] The body weight, BMI and waist circumstancewere significantly decreased in the both groups, butshowed more significantdecreasein the VLCD intervention group （P 〈 0.01 ）. There were no significant difference in bone turnover between the two groups after intervention （ P 〉 0.05）. [ Conclusion] Short- term very low carbohydrate diet intervention can improve body weight, BMI and waist circumstance in overweight or obese subjects while has no significant impact on bone turnover.

关 键 词：VLCD干预 超重 肥胖 骨代谢 

分 类 号：R151.1[医药卫生—营养与食品卫生学]