血清C反应蛋白神经元特异性烯醇化酶糖类抗原199及胃泌素释放肽前体联合检测在肺癌诊断中的应用价值  

Diagnostic value of combination of serum C reactive protein,carcinoembryonic antigen,neuronspecific enolase,carbohydrate antigen 199 and pro-gastrin-releasing peptide in lung cancer

作　　者：李芸[1] 

机构地区：[1]湖南省人民医院呼吸内科,长沙410005

出　　处：《中国肿瘤临床与康复》2016年第2期166-169,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨C反应蛋白(CRP)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、糖类抗原199(CA199)和胃泌素释放肽前体(Pro GRP)联合检测在肺癌诊断中的应用价值。方法选取2013年8月至2015年3月间确诊的67例肺癌患者作为肺癌组,选取同期收治的42例肺部良性疾病患者作为肺部良性疾病组,选取同期收治的41例健康体检者作为健康组。分别测定3组研究对象的血清CRP及肿瘤标志物水平。结果肺癌组患者NSE、CEA、CA199、和Pro GRP血清肿瘤标志物水平均高于肺部良性疾病组及健康组,差异均有统计学意义(均P<0.05)。肺癌组患者CRP水平显著高于健康组,差异有统计学意义(P<0.05)。CRP与血清肿瘤标志物联合检测可提高肺癌诊断的敏感性。结论 CRP与NSE等血清肿瘤标志物联合检测可提高对肺癌诊断的敏感性,具有临床应用价值。Objective To explore the diagnostic value of C reactive protein （ CRP）, carcinoembry- onic antigen （ CEA）, neuron specific （ NSE）, carbohydrate antigen 199 （CA199） and pro-gastrin-releasing peptide （ProGRP） in the diagnosis of lung cancer. Methods From August 2013 to March 2015 in Hunan Provincial People＇s Hospital, 67 patients with lung cancer, 42 patients with benign pulmonary disease and 41 healthy physical examination were enrolled in the study. The levels of serum CRP and four tumor markers of three groups were determined. Results The levels of 4 serum tumor markers in the lung cancer group were significantly higher than those in benign lung disease group and healthy group, with significant differ- ence （P 〈 0. 05 ）. The CRP value in the lung cancer group was significantly higher than that in healthy group, with significant difference （ P 〈 0. 05 ）. And CRP and serum tumor markers combined detection in the diagnosis of lung cancer were significantly improved. Conclusions Combined detection of serum tumor makers such as CRP and NSE can improve the diagnostic sensitivity of lung cancer. It has clinical application value.

关 键 词：肺肿瘤 诊断价值 C反应蛋白 神经元特异性烯醇化酶 癌胚抗原 糖类抗原199 胃泌素释放肽前体 

分 类 号：R734.2[医药卫生—肿瘤]