小牛血去蛋白提取物对恶性肿瘤患者放射性肺炎的疗效  

Effect of calf blood extract on the malignant tumor radiation pneumonia

作　　者：朱中成[1] 魏志江[2] 王明[1] 赵悦[1] 李兴德[1] 张维[2] 

机构地区：[1]河北省沧州市中心医院放疗科,沧州061001 [2]河北省沧州市中心医院肿瘤外一科,沧州061001

出　　处：《中国肿瘤临床与康复》2016年第2期199-202,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨小牛血去蛋白提取物辅助治疗恶性肿瘤患者放射性肺炎的临床疗效。方法选择2013年8月至2014年12月间诊治的82例放射性肺炎患者,根据患者入院顺序分为研究组和对照组,每组各41例。两组患者均给予糖皮质激素、抗生素等常规治疗,研究组患者加用小牛血去蛋白提取物治疗,对两组患者的临床效果进行评价。结果研究组患者的咳嗽、呼吸困难和肺部啰音缓解时间均显著低于对照组,差异均有统计学意义(均P<0.05)。治疗前两组患者的白介素6(IL-6)、IL-10、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)水平的差异均无统计学意义(均P>0.05),治疗后两组患者的IL-6、IL-10、TNF-α和CRP水平较治疗前均明显下降(均P<0.05),研究组患者降低更加明显(均P<0.05)。治疗前两组患者的放射性肺炎分级差异无统计学意义(P>0.05),治疗后两组患者的放射性肺炎分级均显著优于同组治疗前,差异有统计学意义(P<0.05),治疗后研究组患者放射性肺炎分级显著优于对照组,差异有统计学意义(P<0.05)。经过2周治疗,研究组患者的完全缓解率为56.1%,显著高于对照组的31.7%,差异有统计学意义(P<0.05);治疗后研究组患者的部分缓解率、无效率与对照组比较,差异均无统计学意义(均P>0.05)。结论小牛血去蛋白提取物辅助治疗恶性肿瘤患者放射治疗致放射性肺炎能够显著提高临床效果。Objective To investigate the clinical effect of calf blood extract on the malignant tumor radiation pneumonia. Methods According to the order of admission, the 82 cases of radiation pneumonia were divided into study group and control group, with 41 cases in each group. Patients in the two groups were given conventional treatment, such as eortieosteroids, antibiotics, and so on. Patients in the study group were treated with calf blood extract. The clinical effects of two groups of patients was evaluated. Results Cough, dyspnea, pulmonary rales remission time of patients in the study group were significantly lower than those in the control group, and the difference was statistically significant （ P 〈 0. 05 ）. Before treatment, the difference of two groups of patients with interleukin （IL）-6, IL-10 and tumor necrosis factor （TNF）-α, C reactive protein （CRP） levels were not statistically significant （P 〉 0. 05 ）. IL-6, IL-10, TNF-α and CRP were significantly decreased in the two groups after treatment （P 〈 0. 05 ）. The reduction of patients in the study group was more obvious （ P 〈 0. 05 ）. There was no significant difference in the level of radiation pneumonia between the two groups before treatment （ P 〉 0.05 ）. After treatment, the level of radiation pneumonia in the two groups of patients were significantly better than those in the same group before treatment, and the difference was statistically significant （P 〈 0. 05 ）. After treatment, the level of radiation pneumonia in the study group was significantly better than the control group, and the difference was statisti-cally significant （P 〈 0. 05 ）. After 2 weeks of treatment, the complete remission rate of the study group was 56. 1%, significantly higher than that in the control group （31.7%）, and the difference was statistically significant （P 〈 0. 05 ）. After treatment, there was no significant difference in the partial remission rate and the non-efficiency rate between the study group and the

关 键 词：肿瘤 小牛血去蛋白提取物 放射治疗 放射性肺炎 

分 类 号：R730.5[医药卫生—肿瘤]