中肾管附件肿瘤临床病理观察  

The clinical pathology observed of Wolffian adnexal tumor

作　　者：崔红霞[1] 侯燕[1] 眭怡群[1] 陈芳[1] 涂健[1] 冯一中[1] 张永胜[1] 

机构地区：[1]苏州大学附属第二医院病理科,江苏苏州215004

出　　处：《诊断病理学杂志》2016年第2期114-116,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨中肾管附件肿瘤的临床病理特征、免疫组化、鉴别诊断、治疗与预后,以提高对中肾管附件肿瘤的认识,减少误诊及漏诊。方法对1例中肾管附件肿瘤进行临床和病理学观察、免疫组化研究并复习相关文献。结果巨检:卵巢附壁及输卵管系膜处见一大小12 cm×12 cm×12 cm肿块,切面灰白色、质中,局部有黏液感,包膜完整。镜检:肿瘤有纤维包膜,肿瘤组织中见实性片状、小管及小梁状结构,局部区域呈囊性结构,小管周围有基底膜。瘤细胞为低柱状或立方状,部分细胞胞质透明,细胞排列密集,细胞核圆形或卵圆形,无明显异型性,核分裂象罕见。免疫组化示肿瘤细胞vimentin、AE1/AE3、CAM5.2、CK7、WT1和CD99均(+),Ki-67(5%)、CA125、α-inhibin、calretinin、desmin、α-SMA、ER、PR、CD10和EMA均(-)。结论中肾管附件肿瘤是一种少见的具有低度恶性潜能的肿瘤,肿瘤全切加全子宫和双附件切除术以及术后长时间的密切随访是主要的治疗方式。Objective To investigate the clinicopathologic teatures 、 Immunophenotyping, differential diagnosis, treatment and prognosis of wolffian adnexal tumor（WAT）. Improve the understanding of wolffian adnexal tumor, reduce misdiagnosis and missed diagnosis. Methods A case of WAT was studied clinically, histopathologitally with immunohistochemically, and the related literatures were reviewed as well. Results Autopsy：Ovary and mesosalpinx enclosed wall see a size 12 cmx 12 cm × 12 cm lump,grey section, mass medium, local have mucus, membrane integrity. Microscopy： Tumors have fiber capsule, solid flake, small pipe and trabecular structure. Local area show cystic structure. There are tubular basement membrane around it. Tumor cells is low columnar or cubic shape, part of cell cytoplasm is transparent, cell arranged densely populated, the nuclei are round or ovoid, no obvious atypia, fission is rare. Immunohistoehemical tumor cells in Vim, AE1 / AE3, CAM5.2, CK7, WT1, CD99 are positive. Ki-67 （5%）. CA125, Calretinin, alpha inhibin, Des, alpha SMA, ER, PR, CD10, EMA are negative. Conclusions WAT is a rare tumor with low malignant potential, shaver tumor hysterectomy and oophorectomy double is the primary treatment method. In addition, WAT patients should be closely followed up long-term.

关 键 词：中肾管附件肿瘤 病理学 临床 免疫组化 

分 类 号：R737.1[医药卫生—肿瘤]