Oculus眼表综合分析仪测量LASIK术后干眼患者非侵入性泪液功能指标与干眼症状和体征之间的相关性分析  

Correlation between non-invasive tear function indicators and dry eye symptoms,signs in dry eye patients after LASIK by Oculus KeratograPh5M

作　　者：张杰[1] 吴菊芬[1] 王兰[1] 吕菊玲[1] 张鹏[1] 霍淑平[1] 陈金鹏[1] 

机构地区：[1]鄂州市中心医院眼科,湖北省鄂州市436000

出　　处：《眼科新进展》2016年第2期162-164,168,共4页Recent Advances in Ophthalmology

基　　金：湖北省卫生计生委科研基金资助(编号:WJ2015MB190);鄂州市自然科学基金资助(编号:2014ED02)~~

摘　　要：目的探讨Oculus眼表综合分析仪测量准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)术后干眼患者的非侵入性泪液功能指标与干眼症状、体征的相关性。方法选择鄂州市中心医院2014年9月至12月行LASIK且术后1个月被诊断为干眼的患者40例(40眼),Oculus眼表综合分析仪测量非侵入性首次泪膜破裂时间(non-invasive first tear film break-up time,NIBUTf)、非侵入性平均泪膜破裂时间(non-invasive average tear film break-up time,NIBUTav)、Oculus自动干眼分级、下泪河高度(lower tear meniscus hight,LTMH);基础泪液分泌(SchirmerⅠTest,SⅠT)、角膜荧光素染色(corneal fluorescein staining,CFS)评分、患者干眼主观症状评分。采用Spearman秩相关分析NIBUTf、NIBUTav、Oculus自动干眼分级、LTMH与SⅠT、FS、干眼主观症状评分之间的关系。结果 NIBUTf、NIBUTav与Oculus自动干眼分级均呈负相关(r=-0.430,P=0.006;r=-0.747,P=0.000);SⅠT与NIBUTf、NIBUTav、LTMH均呈正相关(r=0.459,P=0.003;r=0.394,P=0.012;r=0.733,P=0.000),SⅠT与Oculus自动干眼分级无相关性(r=-0.259,P=0.107);CFS评分与NIBUTav、LTMH均呈负相关(r=-0.466,P=0.002;r=-0.687,P=0.000),CFS评分与NIBUTf、Oculus自动干眼分级均无相关性(r=-0.189,P=0.244;r=0.301,P=0.059);干眼主观症状评分与NIBUTf、NIBUTav均呈负相关(r=-0.530,P=0.000;r=-0.700,P=0.000),与Oculus自动干眼分级呈正相关(r=0.623,P=0.000)、与LTMH无明显相关性(r=-0.243,P=0.130)。结论 Oculus眼表综合分析仪能客观地测量非侵入性泪液功能指标,与干眼其他指标存在相关性,可作为辅助LASIK术后干眼诊断和随访的有效工具。Objective To evaluate the correlation between non-invasive tear function indicators and dry eye signs , symptoms in dry eye patients after LASIK by Oculus Keratograph5M. Methods Forty cases （ 40 eyes） diagnosed as dry eye at I month after LASIK in Ezhou Central Hospital from September to December 2014 were chosen. Non-invasive first tear film break-up time （ NIBUTf ） , non-invasive average tear film break-up time （ NIBUTav ） . non-invasive lower tear meniscus height （ LTMH ） , oculus automatic dry eye classification were measured with Oculus Keratograph5M, and Schirmer I test （ S IT ） . corneal fluorescein staining score （ CFS ） , dry eye subjective symptom scores were performed in all cases. The correlations analysis between the noninvasive tear function indicators and S IT. FS , dry eye subjective symptom scores were performed by Spearman rank correlation. Results Both NIBUTf and NIBUTav showed negative correlation with Oculus automatic dry eye classification （ r = - 0. 430 . P = 0. 006 ; r = - 0. 747 ,P = 0. 000 ） ; S IT and NIBUTf , NIBUTav. LTMH showed positive correlation（ r = 0. 459 .P = 0. 003 ;r = 0. 394 ,P = 0. 012 ; r = 0. 733 ,P = 0. 000 ） . but there was no correlation with oculus automatic dry eye classification （ r = - 0. 259, P = 0. 107） ;FS and NIBUTav.LTMH showed negative correlation （ r = - 0. 466 ,P = 0. 002 ; r = - 0. 687 .P = 0. 000 ） , but there was no correlation with NIBUTf and oculus automatic dry eye classification（ r = - 0. 189 .P = 0. 244 ; r = 0. 301 ,P = 0. 059） ; Both NIBUTf and NIBUTav showed negative correlation with dry eye subjective symptom scores （ r = - 0. 530 .P = 0. 000 ;r = - 0. 700 ,P = 0. 000 ） , but showed s good positive correlation with oculus automatic dry eye classification （ r = 0. 623 ,P = 0. 000） . There was no correlation between dry eye subjective symptom scores and LTMH （ r = - 0. 243 .P = 0. 130） . Conclrision Oculus Keratograph5M can objectively measure non-rnvasive tear function indicators .which are

关 键 词：干眼 准分子激光原位角膜磨镶术 眼表综合分析仪 非侵入性泪膜破裂时间 

分 类 号：R779.6[医药卫生—眼科]