小梁切除术分别联合Ologen植入与丝裂霉素C治疗青光眼的有效性和安全性对比分析  

Comparison of efficacy and safety between trabeculectomy with Ologen implant and mitomycin C:A Meta-analysis

作　　者：罗丹[1] 温跃春[1] 季青山[1] 

机构地区：[1]安徽医科大学附属安徽省立医院眼科,安徽省合肥市230001

出　　处：《眼科新进展》2016年第2期175-177,共3页Recent Advances in Ophthalmology

摘　　要：目的对比分析小梁切除术分别联合Ologen植入与丝裂霉素C(mitomycin C,MMC)治疗青光眼的有效性和安全性。方法利用计算机检索Medline、EMBASE、Web of Science、Cochrane Central of Controlled Trials、Google Scholar等数据库,检索时间均从建库至2014年1月,并追溯纳入文献的参考文献。将获得的临床对照研究,通过纳入和排除标准限定,经质量评价后,采用Rev Man5.0软件进行Meta分析。结果纳入6篇临床对照研究(小梁切除术联合Ologen植入组114例,小梁切除术联合MMC组123例),质量评分均大于16分,为高质量文献。Meta分析结果显示,Ologen植入组术后患者眼压减低,但眼压降低百分率与MMC治疗组相比无明显差异。两组在青光眼药物种数治疗减少、手术成功率及术后并发症发生率等方面亦无明显差异。结论小梁切除术联合Ologen植入治疗青光眼在长期眼压控制成功率方面与小梁切除术联合MMC治疗效果相当,在避免MMC治疗引发的术后并发症方面无明显优势。Objective To systematically compare the efficacy and safety of trab- eculectomy with Ologen implant and mitomycin C （MMC） for glaucoma. Methods Such databases as Medline, EMBASE, Web of Science, Cochrane Central of Controlled Trials, Google Scholar were searched until January 2014, also the references of included studies were traced. The controlled trials on trabeculectomy ＋ Ologen vs. trabeculecto- my ＋ MMC for glaucoma after study selections were scored highly by Downs and Blacks score. Then meta-analysis was performed using RevMan 5.0 software. Results Six studies involved 114 eyes on trabeculectomy ＋ Ologen and 123 eyes on trabeculectomy ＋ MMC were included in our study. Each study had a score 〉 16 points. The results of me- ta-analysis showed that Ologen implant was associated with a numerically low IOP, but no significant percentage reduction in IOP compared with MMC. There was no signifi- cant difference in the reduction of glaucoma medications, success rate, and incidence of complications. Conclusion Trabeculectomy with Ologen implant is comparable to the use of MMC with a similar long-term success rate. However,it does not seem to of- fer significant advantages of avoiding the potential complications related to MMC.

关 键 词：小梁切除术 青光眼 Ologen植入 丝裂霉素C META分析 

分 类 号：R775[医药卫生—眼科]