Ku蛋白在皮肤血管瘤组织中表达及其临床意义  

Expression of Ku protein in human dermal hemangiomas and its clinical value

作　　者：吴诗诗 王鹰 杨虹[1] 

机构地区：[1]湖北医药学院组织学与胚胎学教研室,十堰442000 [2]深圳市宝安区龙华医院病理科,深圳518001

出　　处：《解剖学杂志》2016年第1期46-48,76,共4页Chinese Journal of Anatomy

基　　金：湖北省教育厅科研重点项目(D20132012)

摘　　要：目的：探讨Ku蛋白在皮肤血管瘤组织中的表达及其临床意义。方法：收集深圳市龙华医院病理科2009-2013年皮肤血管瘤存档蜡块20例，其中男性15例，女性5例。采用免疫组织化学S-P法检测20例皮肤血管瘤及周围正常组织5例中Ku蛋白表达水平，采用HPIAS-1000图文报告管理系统对Ku蛋白的表达进行图像分析，并用SPSS13．0软件对各组免疫组织化学反应阳性颗粒的平均光密度、阳性面积率等做单因素方差分析和SNK（q）检验。结果：Ku蛋白在皮肤血管瘤增生期组织中呈高表达，而在退化期和正常皮肤组织中呈低表达。皮肤血管瘤增生期组织中Ku蛋白的表达明显高于退化期和正常皮肤组织。结论：Ku蛋白在皮肤血管瘤的发生和发展中起重要作用。Objective： To approach the expression and clinical significance of Ku protein in human dermal hemangiomas. Methods： Specimens from 20 cases（15 males and 5 females） of human dermal hemangiomas from the department of pathology in Longhua Hospital of Shenzhen from 2009 to 2013 were collected. We examined the expression of Ku protein in proliferative, involuting hemangiomas and normal skin tissues by using immunohistochemical technique. Average optical density and positive area rates of Ku protein were measured by image analysis（HPIAS-1000）. Results： Expression of Ku protein was significantly higher in the proliferative phase angioma endothelial cells than that in involuting hemangiomas and normal skin tissues. No significant difference was found between the expression of Ku protein in involuting hemangiomas and that in normal skin tissues. Conclusion： The high expression of Ku protein in proliferating hemangiomas indicates that Ku protein may play an important role in the occurrence and development of hemangioma.

关 键 词：皮肤血管瘤 KU蛋白 免疫组织化学 人 

分 类 号：R739.5[医药卫生—肿瘤]