胆总管结石患者血清肿瘤标志物的临床意义  

The clinical significance of serum tumor markers in patients with choledocholithiasis

作　　者：冯洁[1] 沈强[1] 潘勤聪[1] 

机构地区：[1]复旦大学附属上海市第五人民医院消化科,上海200240

出　　处：《胃肠病学和肝病学杂志》2016年第2期212-214,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的研究胆总管结石患者肿瘤标志物水平及其与胆红素之间的关系。方法回顾性分析复旦大学附属上海市第五人民医院收治的胆总管结石患者,所有患者均行磁共振胰胆管造影(MRCP)明确诊断并行经内镜逆行性胰胆管造影术(ERCP)治疗,分析患者CA199、CA50、CEA、CA242、CA724与胆红素水平的相关性,进一步分析其临床意义。结果血清CA199、CA50、CA242在胆总管结石患者阳性率分别为52.5%、23.8%、22.5%,并且随着胆红素水平上升而逐渐升高,经ERCP治疗后均出现不同程度的下降。而血清CA724与CEA在胆总管结石患者阳性率极低。结论血清CA199、CA50、CA242水平受胆总管结石的影响较大,需结合影像学检查及治疗后复查以与消化道肿瘤鉴别。而CEA及CA724在胆总管结石中变化小。Objective To investigate the the clinical significance of serum tumor markers in choledocholithiasis. Methods A retrospective analysis of choledocholithiasis patients in the Fifth People＇ s Hospital of Shanghai, Fudan U- niversity was made to analyze the relationship of serum CA199, CA50, CEA, CA242, CA724 expressions with bilirubin level, all patients accepted ERCP examination and treatment. Results The positive rates of serum levels of CA199, CA50 and CA242 in choledocholithiasis patients were 52.5% , 23.8% , 22.5% , respectively, gradually increased with the increasing of bilirubin level, and declined in a different degree after ERCP treatment. The positive rates of serum CA724 and CEA in choledocholithiasis patients were extremely low. Conclusion Serum CA199, CA50, CA242 are larger influenced by chdedocholithiasis, it is necessary to combine with imaging examination and re-examination after treatment to further identify with digestive tract tumor. The CEA and CA724 have small changes in choledocholithiasis.

关 键 词：胆总管结石 肿瘤标志物 梗阻性黄疸 

分 类 号：R575.62[医药卫生—消化系统]