子宫内膜癌相关细胞因子过表达在肿瘤微环境中的作用研究进展  

Endometrial cancer-related cytokines expression in tumor microenvironment

作　　者：童焰[1] 方玉婷[1] 赖智清 谭布珍[1] 

机构地区：[1]南昌大学第二附属医院妇产科,330006 [2]南昌大学第二附属医院超声科,330006

出　　处：《免疫学杂志》2016年第3期269-273,共5页Immunological Journal

摘　　要：子宫内膜癌为妇科三大恶性肿瘤之一,近年来其发病率呈上升趋势,但其发病机制仍不明确。而在子宫内膜癌中其过表达的细胞因子可以通过各种机制在子宫内膜癌的微环境中参与促进肿瘤细胞增殖、免疫抑制和炎症发生等生物学行为,为子宫内膜癌的侵袭和转移提供更加有利条件,在促进子宫内膜癌的发生发展中扮演着重要的角色。本文就这些过表达的细胞因子在子宫内膜癌中的表达情况及其在肿瘤微环境中的作用进行综述。The incidence of endometrial carcinoma, one of three major malignant tumor of gynaecology, is rising in recent years, but its pathogenesis is still unclear. Over-expression of cytokines in endometrial carcinoma could promote tumor cell proliferation by a variety of mechanisms in the microenvironment of endometrial carcinoma, and also involves in be immunosuppression and inflammation, which provide more favorable conditions for endometrial cancer invasion and metastasis, thus plays an important role in the development and occurrence of endometrial cancer. This paper review the expression of cytokine expression in endometrial carcinoma and its role in the tumor microenvironment.

关 键 词：子宫内膜癌 细胞因子 细胞增殖 免疫抑制 炎症 

分 类 号：R737.33[医药卫生—肿瘤]