眠安宁颗粒联合氟哌噻吨美利曲辛片治疗神经衰弱失眠的临床研究  

Clinical Observation on Mian'anning Granule and Deanxit in the Treatment of Insomnia for Neurasthenia

作　　者：肖展翅 高聚[1] 倪小红[1] 郑操[1] 陈洪汉[1] 

机构地区：[1]湖北省黄冈市中心医院,湖北黄冈438000

出　　处：《中西医结合心脑血管病杂志》2016年第2期121-123,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：湖北省科技厅自然科学基金一般项目(No.2015CFC793)

摘　　要：目的探讨眠安宁颗粒联合氟哌噻吨美利曲辛片(黛力新)对神经衰弱失眠的治疗作用及安全性。方法将95例神经衰弱病人随机分为两组,对照组(47例)口服黛力新,研究组(48例)口服黛力新和眠安宁颗粒治疗,疗程为3周。分别于治疗前及治疗后第1周、2周、3周末用匹兹堡睡眠质量量表(PSQI)、抑郁自评量表(SDS)、焦虑自评量表(SAS)评定治疗效果,用治疗副反应量表(TESS)评定药物不良反应,并将两组评分和不良反应进行比较。结果治疗后2周、3周,两组PSQI、SDS、SAS评分均较治疗前明显改善(P<0.05或P<0.01),且研究组PSQI评分优于对照组(P<0.05);研究组临床疗效总有效率优于对照组(91.67%vs 80.85%,P<0.05);两组均无严重药物不良反应。结论眠安宁颗粒联合黛力新治疗神经衰弱失眠安全有效。Objective To investigate the efficacy and safety of Mian’anning granule（ MAG） and deanxit in the treatment of insomnia for neurasthenia. Methods Ninety-five patients with insomnia for neurasthenia were randomly divided into two groups： The control group（n = 47）treated with deanxit,and the treatment group（n = 48） treated with deanxit plus MAG for 3 weeks. The efficacy were assessed by Pittsburgh sleep quality index（ PSQI）,Self-rating depression scale（ SDS）,Self-rating anxiety scale（ SAS） at the end of 1st,2nd,3rd week. The side effects were assessed by Treatment Emergent Symptom Scale（ TESS）. Results The scores of PSQI,SDS and SAS were improved after treatment,which were better than that in control group（P 〈 0. 05）. The total clinical effective rate was 91.67% in treatment group,which was higher than that in control group（ 80. 85%,P 〈 0. 05）. There was no side effects in two groups. Conclusion MAG and deanxit have effect on insomnia for neurasthenia.

关 键 词：神经衰弱 失眠 眠安宁颗粒 氟哌噻吨美利曲辛片 匹兹堡睡眠质量量表 

分 类 号：R749.71[医药卫生—神经病学与精神病学]