代谢组学在牙周病学中的应用  

Applications of metabonomics in periodontology

作　　者：陈慧文[1] 宋忠臣[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院.口腔医学院牙周病科,上海200011

出　　处：《口腔医学》2016年第2期178-181,共4页Stomatology

基　　金：国家自然科学基金资助项目(2015-0348)

摘　　要：牙周炎是一种以牙周组织破坏为特征的慢性炎症性疾病,牙菌斑生物膜是其发病的始动因子,此外牙周炎还受局部促进因素的影响和全身因素的调控,但其具体的发病机制尚不完全清楚。近年来,随着代谢组学的兴起和发展,探索牙周疾病的致病过程和机理有了新的切入点。本文就代谢组学的概念、特点、检测手段以及代谢组学技术在牙周病学中的应用作一综述。Periodontitis is a chronic inflammatory disease characterized by the destruction of periodontal tissues. Dental plaque is the dominant pathogenic factor. In addition, periodontitis is also influenced by local contributing factors and systemic factors. The specific pathogenesis has not yet been clarified. Recently, with the rapid development of metabonomics, there has been a new point of penetra- tion to explore the mechanism of periodontitis. In this article, the concept, characteristics, detecting method and the application of metabonomic in periodontitis were reviewed.

关 键 词：代谢组学 液相色谱质谱联用技术 牙周炎 

分 类 号：R781.4[医药卫生—口腔医学]