CEACAM1与CD105在肾细胞癌中的表达及意义  

Expression of CEACAM1 and CD105 in Renal Cell Carcinoma and its Correlation with MVD

作　　者：康照鹏[1] 谭艳[1] 王丽欣[2] 刘俊[1] 朱保平[3] 谢胜[1] 

机构地区：[1]湖北医药学院附属人民医院男科,湖北十堰442000 [2]湖北医药学院附属人民医院耳鼻咽喉头颈外科,湖北十堰442000 [3]武汉大学附属中南医院泌尿外科,湖北武汉430071

出　　处：《湖北医药学院学报》2015年第6期573-576,F0002,共5页Journal of Hubei University of Medicine

摘　　要：目的：观察细胞黏附分子1（CEACAM1）与CD105分子在肾细胞癌（RCC）中的表达变化,研究其与肿瘤血管生成、肿瘤侵袭和转移的关系。方法：采用免疫组化SP法,检测47例肾细胞癌组织中CEACAM1和CD105的表达情况;并记录微血管密度（MVD）值,对肾细胞癌及癌旁正常肾组织中CEACAM1和CD105的表达情况进行相关分析。结果：⑴CEACAM1在肾癌中表达强度明显低于癌旁正常组织（P〈0.05）;CEACAM1在Ⅰ-Ⅱ期中表达明显高于Ⅲ-Ⅳ期（P〈0.05）。⑵肾癌组织中CD105-MVD值明显高于癌旁正常组织MVD,二者相比差异有统计学意义（P〈0.01）。CD105-MVD值在各病理分级G1、G2、G3组间两两比较,差异均有统计学意义（P〈0.05）,在不同临床分期中表达有显著差异（P〈0.01）。⑶CEACAM1与CD105-MVD表达呈负相关（r=-0.427,P〈0.01）。结论：⑴肾癌中存在CEACAM1的表达下调和CD105-MVD升高,肾细胞癌中CEACAM1与CD105-MVD存在负相关。⑵CEACAM1在肾癌中的表达促进了肾细胞癌微血管的生成,提示CEACAM1可以作为抗肿瘤血管生成疗法的治疗靶点之一。Objective To investigate the expression of CEACAM1,Endoglin（ CD105） and the microvessel density（ MVD） in renal cell carcinomas,and explore the role of CEACAM1 and CD105 in the growth,invasion and metastasis of renal cell carcinomas.Methods The specimens from 47 cases of renal cell carcinomas and 15 cases of normal kidney tissues were determined by the immunohistochemical SP method for the expression of CEACAM1 and CD105.MVD was calculated under the microscope by labeling the endothelial cells of blood vessels.Results The expression of CEACAM1 level in renal cell carcinoma was lower than of normal kidney（ P 0. 05）. The CEACAM1 level in Ⅰ - Ⅱ clinical stages were significantly higher than those in Ⅲ - Ⅳ stages（ P〈0.05）.The mean CD105-MVD in renal cell carcinomas was obviously higher than in normal tissues（ P〈0.01）.There were significant differences of CD105-MVD among three histologic grades（ P 0.05） and different clinical stages（ P〈0.01）. CEACAM1 was negatively correlated with CD105- MVD（ r =- 0. 427,P 0. 01）. Conclusion The expression of CEACAM1 and CD105-MVD were downregulated and upregulated,respectively.CEACAM1 may be negatively correlated with CD105-MVD in renal cell carcinomas.The expression of CEACAM1 may promote angiogenesis in renal cell carcinoma,which suggest that CEACAM1 could be a therapeutics target in the antiangiogenesis of renal cell carcinoma.

关 键 词：细胞黏附相关分子1 CD105 微血管密度 肾细胞癌 

分 类 号：R737.11[医药卫生—肿瘤]