TSG101在病毒出芽过程中的作用及其机制  

The Action and Mechanism of TSG101 during Virus Budding

作　　者：许岩[1] 张莹[2] 

机构地区：[1]中国医科大学,临床医学七年制辽宁沈阳110000 [2]中国医科大学科学实验技术中心三部,辽宁沈阳110013

出　　处：《微生物学杂志》2015年第6期90-95,共6页Journal of Microbiology

基　　金：辽宁省自然科学基金项目(2014021095);沈阳市科学技术项目(F12-264-4-01)

摘　　要：TSG101基因是新发现的抑癌基因候选者,定位于人类11号染色体p1511-p1512,其编码产物TSG101蛋白N端区域与泛素结合酶(UBC)同源。近年来研究发现,TSG101基因具有多种重要的功能,与多种病毒出芽密切相关,所以TSG101可作为一个新的抗病毒靶点。本文主要从TSG101在多种病毒(HIV、IAV、MARV、ASV等)出芽过程中扮演的角色,TSG101与多种蛋白(泛素、Nedd4、ARMMs、Tom1、Gag、VP40、NP等)的相互作用进而辅助病毒出芽的机制,以及TSG101抑制剂的研究等方面进行阐述。TSG101 gene is a newly discovered candidate of tumor suppressor genes and locates in the human chromosome XI p1511-p1512. Its product TSG101 protein N-terminal region is isogenous with ubiquitin-conjugated domain （UBC）. It was found in recent studies that TSG101 has many important functions and it is closely associated with viral budding, therefore, TSG101 would be a useful anti-virus target for drug design. The role of TSG101 played in the process of virus budding （ such as HIV, IAV, MARV, ASV） , the mutual action mechanism of TSGIO1 and proteins （ubiquitin, Nedd4, ARMMs, Total, Gag, VP40, NP etc. ） in assisting virus budding, and TSG101 inhibitors and other aspects were elaborated in this paper.

关 键 词：TSG101 UBC 病毒出芽 抗病毒靶点 

分 类 号：Q939.4[生物学—微生物学]