纤维蛋白原和血小板平均体积与急性脑梗死相关性研究  

Correlation Studies of Fibrinogen and Mean Platelet Volume with Acute Cerebral Infarction

作　　者：邓耀芳[1] 邱观养[1] 黄丹丹[1] 黄国敏[1] 韦恒宇 

机构地区：[1]广东省高州市人民医院,广东高州525200

出　　处：《中国医学创新》2016年第2期1-4,共4页Medical Innovation of China

基　　金：茂名市科技计划项目(20150330)

摘　　要：目的:探讨纤维蛋白原(FIB)和血小板平均体积(MPV)与急性脑梗死的关系。方法:选取2015年1月1日-5月30日收治入本院进行治疗的200例急性脑梗死患者(观察组)以及同期于本院进行健康体检的100例健康人士(对照组)作为研究对象,同时按照美国国立卫生研究院卒中量表(NIHSS)评分将急性脑梗死患者分为轻度、中度、重度3个亚组。比较观察组与对照组血小板以及凝血系统情况,以及轻度、中度、重度亚组间的纤维蛋白原水平和血小板水平体积。结果:观察组血小板(PLT)含量为(198.32±54.47)×109/L,低于对照组的(219.41±52.13)×109/L;观察组平均血小板容积(MPV)为(10.16±1.44)f L,高于对照组的(9.12±1.31)f L;血小板分布宽度(PDW)为(17.11±2.23)%,高于对照组的(16.21±0.91)%,纤维蛋白原(FIB)水平为(3.79±0.78)g/L,高于对照组的(3.25±0.41)g/L,差异均有统计学意义(P<0.05)。多因素Logistic回归性分析表明MPV与FIB均为脑梗死独立危险因素;3个亚组FIB水平比较差异有统计学意义(P<0.05),且FIB水平与患者精神功能障碍程度呈正相关。结论:MPV与FIB可能为急性脑梗死发病的重要危险因素,且FIB水平越高,患者精神损伤程度越严重,因此,检测急性脑梗死患者MPV与FIB水平参数变化,对其治疗具有一定帮助,值得临床应用。Objective：To investigate the relationship between the fibrinogen（FIB） and mean platelet volume （MPV） with acute cerebral infarction.Method：200 patients with acute cerebral infarction and 100 healthy people for physical examination at the same period in our hospital from January 1,2015 to May 30,2015 were selected as the observation group and the control group,at the same time,according to the national institutes of health stroke scale（NIHSS） scores,the patients with acute cerebral infarction were divided into mild, moderate,severe three subgroups.The platelet and coagulation system of the observation group and the control group were compared,as well as the fibrinogen levels and platelet volume level among mild,moderate,severe subgroups were compared.Result：The content of platelet of the observation group was （198.32±54.47）×10^9/L, which was significantly lower than （219.41±52.13）×10^9/L of the control group,the mean platelet volume of the observation group was （10.16±1.44）fL,which was significantly higher than （9.12±1.31）fL of the control group,the platelet distribution width（PDW） of the observation group was （17.11±2.23）%,which was significantly higher than （16.21±0.91）% of the control group,the fibrinogen（FIB） of the observation group was （3.79±0.78）g/L,which was significantly higher than （3.25±0.41）g/L of the control group,the differences were statistically significant（P〈0.05）.The multi-factor Logistic regression analysis showed that MPV and FIB were independent risk factors for cerebral infarction.The differences were statistically significant in FIB level among three subgroups（P〈0.05）,and FIB level and the degree of the patients with mental disorders were positively correlated.Conclusion：MPV and FIB may be the important risk factors of acute cerebral infarction incidence,and FIB level is higher,the more severe of trauma patients,therefore,the detection of MPV and FIB levels changes inpatients with acute cerebral infarction,has

关 键 词：纤维蛋白原水平 血小板平均体积 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]