PSA、PSAD、PSAT及f／tPSA与前列腺患者病理分期的相关性研究  

Correlation between PSA, PSAD, PSAT, f/tPSA and pathological stage of prostate cancer

作　　者：沈滔[1] 李超[1] 

机构地区：[1]沈阳二四二医院泌尿外科,110034

出　　处：《国际医药卫生导报》2016年第3期323-325,共3页International Medicine and Health Guidance News

摘　　要：目的研究PSA、PSAD、PSAT及f／tPSA与前列腺癌病理分期的相关性。方法以本院2013年5月至2015年5月经病理证实的80例前列腺癌患者为研究对象，选择同期60例前列腺增生患者为对照组，所有患者术前均行PSA、PSAD、PSAT、f／tPSA检测，比较两组各项PSA相关指标，并分析上述指标与前列腺癌病理分期的相关性。结果两组PSA、PSAD、PSAT及f／tPSA比较差异有统计学意义（P〈0．05）。不同临床分期前列腺癌患者血清PSA、PSAD、PSAT及f／tPSA值比较差异均有统计学意义（P〈0．05）。Spearman等级相关性分析PSA、PSAD、PAST、f／tPSA与前列腺癌临床分期相关（r值分别为0．62、0．45、0．46、0．58，P〈0．05）。结论PSA、PSAD、PSAT及f／tPSA对前列腺癌、前列腺癌临床分期诊断有重要价值。Objective To study the correlation between PSA, PSAD, PSAT, f/tPSA and pathological stage of prostate cancer. Methods 80 patients pathologically confirmed as prostate cancer admitted in our hospital from May 2013 to May 2015 were selected as the study object. Another 60 patients with prostatic hyperplasia in the same period were selected as control group. All patients underwent PSA, PSAD, PSAT and f/tPSA detection before operation. PSA related indexes in two groups were compared. The correlation between above indexes and pathological stage of prostate cancer was analyzed. Results There were statistically significant differences in PSA, PSAD, PSAT and f/tPSA between two groups （P〈0.05）. There were statistically significant differences in serum PSA, PSAD, PSAT and f/tPSA values among patients with prostate cancer of different clinical stages （P〈0.05）. Spearman correlation analysis showed that PSA, PSAD, PAST, f/tPSA were correlated with the clinical stage of prostate cancer （r=0.62, 0.45, 0.46, 0.58, P〈0.05）. Conclusion PSA, PSAD, PSAT and f/tPSA are of important value in the diagnosis of prostate cancer and its clinical stage.

关 键 词：前列腺特异抗原 前列腺特异抗原密度 前列腺癌 病理分期 

分 类 号：R737.25[医药卫生—肿瘤]