两种试剂检测孕妇血清甲状腺过氧化物酶自身抗体的对比分析  

Comparative analysis of two reagents in detection of serum thyroid peroxidase autoantibodies of pregnant Women

作　　者：谢美华[1] 胡桂玉 郑惠兰[1] 胡长英 

机构地区：[1]福建中医药大学第五临床医学院三明市第二医院检验科,福建三明366000 [2]福建省永安市妇幼保健院检验科,福建三明366000

出　　处：《中国医药科学》2015年第23期120-122,共3页China Medicine And Pharmacy

摘　　要：目的探讨两种试剂检测孕妇血清甲状腺过氧化物酶自身抗体结果的可比性。方法分别采用两种试剂测定313例孕妇血清TPOAb水平。结果血清TPOAb低浓度和高浓度时,两种试剂的测定结果比较差异有统计学意义(P<0.05),TPOAb中浓度两种试剂的测定结果比较差异无统计学意义(P>0.05),两种试剂对甲状腺功能紊乱组的检出阳性率比较无统计学差异,而对非甲状腺功能紊乱组的阳性检出率有明显差异(P<0.01)。结论试剂B适用于大批量孕妇血清TPOAb筛查和临床早期诊断,试剂A更适用于甲状腺功能紊乱者的临床诊断及疗效监测;两种试剂结合使用,不仅提高了测定准确性,而且节约了试剂成本。Objective To explore comparability of two reagents in detection of serum thyroid peroxidase autoantibodies（TPOAb） of pregnant women. Methods Serum TPOAb levels of 313 pregnant women were detected by two reagents respectively. Results Determination results of two reagents at low concentration and high concentration of serum TPOAb had statistical significance when they were compared（P〈0.05）.Determination results of two reagents at moderate concentration of TPOAb had no statistical significance when they were compared（P〉0.05）.Positive rate of detection by two reagents of the thyroid dysfunction group had no comparatively statistical significance. But positive rate of detection by two reagents of the non-thyroid dysfunction group had comparatively statistical significance（P〈 0.01）. Conclusion Reagent B is applied to screening and clinical early detection of serum TPOAb of mass pregnant women while reagent A is more applied to clinical diagnosis and curative effect detection of patients with thyroid dysfunction.Combined use of two reagents can not only improve accyracy of detection,but also save costs of reagents.

关 键 词：甲状腺过氧化物酶 自身抗体 自身免疫性甲状腺疾病 甲状腺功能紊乱 

分 类 号：R151[医药卫生—营养与食品卫生学]