胃癌根治术围手术期应用ω-3多不饱和脂肪酸的临床疗效研究  

Clinical efficacy of application ofω-3 polyunsaturated fatty acids in perioperative period of radical operation for gastric cancer

作　　者：李伟学[1] 邬善敏[2] 曾涛[1] 

机构地区：[1]武汉科技大学附属汉阳医院普外科,湖北武汉430050 [2]武汉大学人民医院肝胆腔镜外科,湖北武汉430060

出　　处：《海南医学院学报》2016年第8期803-806,共4页Journal of Hainan Medical University

基　　金：湖北省教育厅科学研究计划资助项目(Q20151909)~~

摘　　要：目的:研究胃癌根治术围手术期应用ω-3多不饱和脂肪酸对患者营养状况、炎症反应以及免疫功能的调节作用。方法:选择在我院接受胃癌根治术的86例患者进行研究,随机分为两组,ω-3PUFAs组接受ω-3多不饱和脂肪酸联合常规静脉营养支持,对照组仅接受常规静脉营养支持。手术前后测定两组血清营养指标,手术后测定两组血清中炎症指标以及肿瘤组织中免疫分子。结果:手术前1d和手术后3d时,ω-3PUFAs组血清RBP、PA、RTF、PEPT1、ghrelin含量明显高于对照组;手术后3d时,ω-3PUFAs组血清CC16、α-MSH、HSP70含量明显高于对照组,LBP、sCD14含量低于对照组;ω-3PUFAs组肿瘤组织中B7-H1、B7-H4、CD157、CD133的含量低于对照组,CD11c的含量明显高于对照组。结论:胃癌根治术围手术期应用ω-3多不饱和脂肪酸能够改善患者的营养状况、减轻手术创伤所引起的术后炎症反应、调节肿瘤组织中免疫分子的表达。Objective： To study the regulating effect of application of ω-3 polyunsaturated fatty acids in perioperative pe- riod of radical surgery for gastric cancer on patients＇ nutritional status, inflammatory response and immune function. Methods： A total of 86 cases of patients receiving radical operation for gastric cancer in our hospital were selected and randomly divided into two groups, ω-3 PUFAs group received ω-3 polyunsaturated fatty acids combined with conventional intravenous nutritional support and control group only received conventional intravenous nutritional support. Serum nutrition indicators of two groups were detected before and after surgery, and inflammation indicators in serum as well as immune molecules in tumor tissue of two groups were detected after surgery. Results： At day 1 before operation and day 3 after operation, serum RBP, PA, RTF, PEPT1 and ghrelin contents of ω-3 PUFAs group were significantly higher than those of control group; at day 3 after opera-tion, serum CC16, ω-MSH and HSP70 contents of ω-3 PUFAs group were significantly higher than those of control group, while LBP and sCD14 contents were significantly lower than those of control group B7-H1, B7-H4, CD157 and CD133 contents in tumor tissue of ω-3 PUFAs group were significantly lower than those of control group, while CDllc content was sig- nificantly higher than that of control group. Conclusion.. Application of ω-3 polyunsaturated fatty acids in perioperative period of radical operation for gastric cancer can improve patients nutritional status, reduce postoperative inflammatory response caused by surgical trauma and regulate the expression of immune molecules in tumor tissue.

关 键 词：胃癌 Ω-3多不饱和脂肪酸 营养状况 炎症反应 免疫应答 

分 类 号：R735.2[医药卫生—肿瘤]