阿魏酸/钾/β-环糊精金属有机骨架包合物的制备工艺优化  

Optimization of the Preparation Technology of Ferulic Acid/K/β-CD/Metal Organic Framework Inclusion

作　　者：杨小宁[1] 张秀梅[1] 吴连贺 沙靖全[1] 杨西亚 方璐[1] 

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《中国药房》2016年第7期936-938,共3页China Pharmacy

基　　金：国家自然科学基金资助项目(No.21271089)

摘　　要：目的:制备阿魏酸/钾/β-环糊精金属有机骨架包合物(FA/K/β-CD/MOF),并优化其制备工艺。方法:利用溶剂热法制备K/β-CD/MOF,以其为包合材料、FA为主药,采用研磨法制备FA/K/β-CD/MOF。以主药-包合材料摩尔比、研磨时间、滴加时间、包合温度为考察因素,以包合率为评价指标,通过正交设计优化处方工艺。采用红外光谱和差示扫描量热法对所制FA/K/β-CD/MOF进行鉴定,并测定其包合率和溶解度。结果:最优处方工艺为主药-包合材料摩尔比3∶1、滴加时间60 min、包合温度40℃、包合时间60 min;所制得的FA/K/β-CD/MOF已经构成一种新的物相,其平均包合率为(18.0±1.6)%,RSD为0.9%(n=6),其溶解度是FA的15倍(9.582 mg/ml vs.0.647 mg/ml)。结论:成功制得FA/K/β-CD/MOF,且处方工艺合理、可行。OBJECTIVE： To prepare Ferulic acid/K/β-CD/metal organic framework （FA/K/fl-CD/MOF） inclusion, and to optimize its preparation technology. METHODS： K/β-CD/MOF was synthesized by solvotbermal method as inclusion material. Using FA as main component, FA/K/β-CD/MOF was prepared by grinding method. The preparation technology was optimized by orthogonal test using mole ratio of main component-inclusion material, grinding time, dropping time and inclusion temperature as factors, inclusion rate as index. Prepared FA/K/β-CD/MOF was indentified by IR spectrum and DSC, and inclusion rate and dissolution rate were determined. RESULTS： Optimized preparation technology was as follows as mole ratio of main main component to inclusion material 3 ： 1, dropping time 60 rain, inclusion temperature 40 ℃, inclusion time 60 min. Prepared FA/K/β-CD-MOF had already formed a new kind of phase, and its average inclusion rate was （18.0 ± 1.6）% （RSD=0.9%, n=6）; its solubility was 15 times as much as FA （9.582 mg/ml vs. 0.647 mg/ml）. CONCLUSIONS： FA/K/β-CD/MOF is prepared successfully; and the preparation technology is reasonable and feasible.

关 键 词：阿魏酸 环糊精金属有机骨架 包合物 正交设计 

分 类 号：R943[医药卫生—药剂学]