串联重复序列在鼠疫菌基因分型中的应用  

The application of the tandem repeats in the Yersinia pestis genotyping

作　　者：王海峰[1] 刘合智[1] 杨顺林[1] 周松[1] 白雪薇[1] 杨晓燕[1] 张懿晖[1] 陈凯乐 梁莹[2] 史献明[1] 

机构地区：[1]河北省鼠疫防治所,河北张家口075000 [2]中国疾病预防控制中心传染病预防控制所,北京102206

出　　处：《中国媒介生物学及控制杂志》2016年第1期89-91,共3页Chinese Journal of Vector Biology and Control

基　　金：河北省卫生厅青年科技基金(ZL20140119)~~

摘　　要：鼠疫为危害人类健康的甲类传染病,由于我国存在着多种类型的鼠疫疫源地,鼠疫菌的特征及致病力不同,因此将不同疫源地的菌株进行基因分型,探讨其亲缘关系,对于鼠疫突发疫情的追溯具有重要意义。多位点可变数目串联重复序列分析方法被认为分型能力较好,但是可变数目串联重复序列(VNTR)位点的选择是分型的关键所在,该文主要介绍VNTR在鼠疫菌基因分型中的应用进展,为基因分型提供参考。The plague is categorized as a Class A infectious disease in China. Plague foci are widely distributed, and strains have different features and varied virulence in China. It is of great significance for deducing the sudden outbreak of plague and terrorist attack detection, with the strains of different foci for genotyping. The choice of tandem repeats loci is the key of the multiple loci vntr analysis （MLVA） classification results. This assay mainly introduces tandem repeats in Yersinia pestis genotyping in application progress, and provides a reference for other workers in genotyping.

关 键 词：可变数目串联重复序列 多位点可变数目串联重复序列分析 基因分型 鼠疫菌 

分 类 号：R254.8[医药卫生—中医内科学]