随访间血压变异性对阿尔茨海默病患者认知功能变化的影响  

Effect of visit-to-visit blood pressure variability on the cognitive decline in patients with Alzheimer's disease

作　　者：王芳[1] 吴睿[2] 刘合玉[2] 

机构地区：[1]郑州大学第二附属医院硕士研究生,郑州450000 [2]郑州大学第二附属医院神经康复科,郑州450000

出　　处：《重庆医科大学学报》2016年第1期73-75,共3页Journal of Chongqing Medical University

摘　　要：目的:观察随访间血压波动对阿尔茨海默病(Alzheimer disease,AD)患者认知功能降低变化的影响,探讨血压波动与认知功能降低之间的关系。方法:选取111位轻中度AD患者完成为期1年的随访。用简明精神状态量表(mini-mental state examination,MMSE)评估认知功能,详细记录其血压波动情况。用关联性分析和多元逐步回归分析探索两者之间的关系。结果 :多元逐步回归分析显示仅动脉血压波动可以解释MMSE评分的降低。结论:随访间血压变异性是评估AD患者认知功能恶化进程的一个重要指标。Objective：To investigate whether visit-to-visit blood pressure variability influences the rate of cognitive decline in Alzheimer disease（AD）patients. Methods：A total of 111 patients with mild to moderate AD have completed this evaluation. Assessment of cognitive function was conducted using mini-mental state examination（MMSE） and the variation of blood pressure was recorded. Correlating analyses and multiple stepwise regression analysis were used to do statistical analysis. Results：Multiple stepwise regression analysis showed that only arterial blood pressure variability can explain the decrease in MMSE score. Conclusion：Follow-up blood pressure variability is an important evaluation index of cognitive function deterioration process.

关 键 词：简明精神状态量表 阿尔茨海默病 随访间血压波动 认知功能 

分 类 号：R741.02[医药卫生—神经病学与精神病学]