CDC7和MCM4在子宫内膜腺癌中的表达及意义  

Expressions and significance of CDC7 and MCM4 in endometrial adenocarcinoma

作　　者：徐瑞云[1] 严晓丽[1] 石建芹[1] 严鹏[1] 郑纪宁[1] 

机构地区：[1]承德医学院病理教研室,河北承德067000

出　　处：《中国妇幼保健》2016年第5期1048-1051,共4页Maternal and Child Health Care of China

基　　金：河北省重点学科建设项目资助(031412)

摘　　要：目的探讨子宫内膜腺癌中CDC7和MCM4的表达及意义。方法收集标本140例,其中正常子宫内膜组织40例,子宫内膜腺癌标本100例,用免疫组化SP法分别检测CDC7和MCM4的表达情况。结果 CDC7和MCM4在子宫内膜腺癌中的表达率明显高于正常子宫内膜正常组织(P<0.05),二者的表达与浸润肌壁深度、分化程度、FIGO分期及淋巴结转移有关(P<0.05),与年龄无关(P>0.05),且二者在子宫内膜腺癌中的表达呈正协同作用(r=0.330,P<0.05)。结论 CDC7和MCM4参与了子宫内膜腺癌的发生发展,二者异常的蛋白表达可能是子宫内膜腺癌发病的重要环节。Objective To explore the expressions and significance of CDC7 and MCM4 in endometrial adenocarcinoma. Methods A total of 140 specimens were collected, including 40 normal endometrium specimens and 100 endometrial adenocarcinoma specimens. Immu-nohistochemical SP method was used to detect the expressions of CDC7 and MCM4. Results The expression rates of CDC7 and MCM4 in endometrial adenocarcinoma were statistically significantly higher than those in normal endometrium （ P〈0. 05 ）, which were correlated with the depth of myometrial infiltration, differentiation degree, FIGO stage, and lymph node metastasis （ P〈0. 05 ）, and they were not correlated with age （ P〉0. 05 ） , there was a positively synergistic effect between CDC7 expression and MCM4 expression in endometrial adenocarcinoma （ r = 0. 330, P〈0. 05 ） . Conclusion CDC7 and MCM4 are involved in occurrence and development of endometrial adenocarcinoma, the abnormal expressions of CDC7 and MCM4 may be important parts for onset of endometrial adenocarcinoma.

关 键 词：子宫内膜腺癌 CDC7 MCM4 免疫组化 

分 类 号：R737.3[医药卫生—肿瘤]