基于多元多水平模型的阿尔茨海默病认知与抑郁关系及其影响因素研究  

The Relation and Influencing Factors Regarding Cognition and Depression Among Patients with Alzheimer's Disease Based on Multivariate Multilevel Models

作　　者：宋泽婧 邢敏[1] 王晶莹[1] 翟俊伟[1] 余红梅[1] 

机构地区：[1]山西医科大学卫生统计学教研室,030001

出　　处：《中国卫生统计》2016年第1期9-11,共3页Chinese Journal of Health Statistics

基　　金：国家自然科学基金资助项目(81373106)

摘　　要：目的探讨阿尔茨海默病（Alzheimer＇s disease,AD）患者认知与抑郁之间的相关关系及其影响因素。方法基于对104名AD患者随访资料,认知功能的调查采用蒙特利尔认知评估量表（Montreal cognitive assessment,MoCA）,抑郁状态的评定采用老年抑郁量表（geriatric depression scale,GDS）,拟合多元多水平模型。结果以AD患者认知功能及抑郁状态同为反应变量时,在个体和测量时点水平上,AD患者认知功能及抑郁状态具有相关性且为负相关,相关系数分别为-0.685（χ~2=19.61,P〈0.001）和-0.354（χ~2=34.79,P〈0.001）。影响AD患者认知功能的因素为受教育程度、性格、业余爱好、体育活动、读书看报、铝制炊具、限制饮食和高血压,影响AD患者抑郁状态的因素有婚姻状况、退休前职业、经常做家务、读书看报、铝制炊具、限制饮食及高血压。结论 AD患者的认知功能及抑郁状态呈负相关,且与多种共同因素有关。Objective To explore the relations and the influencing factors between cognition and depression among pa- tients with Alzheimer＇s disease（AD）. Methods Based on 104 AD patients＇ follow-up data, Montreal cognitive assessment （Mo- CA） and the Geriatric Depression Scale（GDS） were used to assess cognition status and depression,respectively. Multivariate multilevel model was then fitted. Results With cognition and depression as the dependent variables, AD patients＇ cognition and depression were negatively correlated at individual level and observation time level and the correlation coefficients were -0. 685 （X2 = 19. 61, P 〈 0. 001 ） and - 0, 354 （X2 = 34.79, P 〈 0. 001 ）. Educational level, character, hobbies, sports activities, reading books or newspapers, aluminum cooking utensils use, dietary restriction and hypertension were the significant factors for patients＇ cognition;Marital status, occupation, doing housework, reading books or newspapers, aluminum cooking utensils use, dietary re- striction and hypertension were the significant factors for patients＇ depression. Conclusion AD patients＇ cognition was negative- ly associated with depression, and they were influenced by many common factors.

关 键 词：多元多水平模型 阿尔茨海默病 认知功能 抑郁状态 

分 类 号：R749.16[医药卫生—神经病学与精神病学]