血管内皮生长因子基因Rs3025039多态性与年龄相关性黄斑变性关联性研究的Meta分析  

A meta- analysis of the correlation between vascular endothelial growth factor polymorphism( Rs3025039) and age- related macular degeneration

作　　者：向伟[1] 迟昊[1] 薛中淇 张雯[1] 庄文娟 

机构地区：[1]宁夏医科大学临床医学院,宁夏银川750004 [2]宁夏人民医院眼科医院,宁夏银川750001

出　　处：《宁夏医学杂志》2016年第2期126-129,共4页Ningxia Medical Journal

基　　金：国家自然科学基金资助项目(81460093);宁夏对外科技合作项目(2014ZYH65)

摘　　要：目的评价血管内皮生长因子（VEGF）基因Rs3025039基因多态性与年龄相关性黄斑变性（AMD）的关联性。方法从PUBMED、EMBASE、中国知网（CNKI）和万方医学网等检索VEGF Rs3025039基因多态性与公开发表的AMD论文,使用STATA 12.0软件,采用比值比（OR）及95%可信区间（95%CI）作为效应指标,分析VEGF基因Rs3025039多态性位点与AMD的关系,同时评价所纳入研究的异质性及发表偏倚。结果共有5篇VEGF基因Rs3025039多态性与AMD关联性的公开发表论文被纳入本研究,包括病例1 290例,对照1 021例。分析结果显示,VEGF Rs3025039 T等位基因相较C等位基因的合并OR值为1.13,95%,CI为0.82~1.56;遗传显性模式和隐性模式合并的OR值以及95%CI分别为1.24（0.85~1.82）和1.07（3.20~0.36）;纯合基因型TT相对于CC的合并OR值及95%CI为1.17（0.37~3.76）;杂合基因型CT相对于CC的合并OR值及95%CI为1.24（0.97~1.60）,上述分析数比较,差异无统计学意义（P〉0.05）。按照种族进行亚组分层分析中也未发现VEGF Rs3025039是AMD的易感位点。结论 VEGF Rs3025039的T等位基因和AMD可能没有关联性。Objective To evaluate the relationship between vascular endothelial growth factor polymorphism（ rs3025039） and AMD utilizing pooled- analysis. Methods All eligible published literatures with regarding to rs3025039 and AMD were retrieved from searching PUBMED,EMBASE,CNKI and Wanfang Med Online. STATA 12. 0 software was used,odds ratio（ OR） and 95% confidence interval（ 95% CI） were conducted to assess the strength of association pertaining to VEGF rs3025039 polymorphism and risk of AMD development. In the meantime,heterogeneity between identified studies and publication bias were also performed. Results Total five case- control studies with 1290 AMD cases and 1 021 controls were recruited into this study. The meta- analysis revealed that the combined odds ratio（ OR） for T allele was 1. 13（ 95% CI： 0. 82 ~ 1. 56） times was higher than C allele. The OR of dominant model and recessive model were 1. 24（ 0. 85 ~ 1. 82） and 1. 07（ 3. 20 ~ 0. 36） respectively. The OR for homozygous TT and CC was 1. 17（ 0. 37 ~ 3. 76）,for heterozygous CT and CC was 1. 24（ 0. 97 ~ 1. 60）. However,all P values were more than 0. 05 and there were no significant differences.Stratifying analysis by ethnicity indicated no correlation on VEGF rs3025039 polymorphism and susceptibility to AMD. Conclusion The VEGF T allele has no relationship with AMD development.

关 键 词：血管内皮生长因子 多态性 年龄相关性黄斑变性 META分析 

分 类 号：R774.5[医药卫生—眼科]