CYFRA21-1、CA19-9、CEA及其联合检测在鉴别良恶性胸腔积液中的临床价值  

Clinical value of detection and combined detection of CYFRA21-1, CA19-9 and CEA in the identification between benign and malignant pleural effusion

作　　者：孙春霞[1] 

机构地区：[1]河南中医学院第三附属医院检验科,郑州市450000

出　　处：《实用检验医师杂志》2015年第4期233-235,共3页Chinese Journal of Clinical Pathologist

摘　　要：目的探讨肿瘤标志物细胞角蛋白片段(cytokeratin fragment antigen 21-1,CYFRA21-1)、糖链抗原19-9(carbohydrate antigen 19-9,CA19-9)、癌胚抗原(carcino-embryonic antigen,CEA)及其联合检测在鉴别良恶性胸腔积液中的临床价值。方法选择2013年10月-2015年10月于我院就诊的80例胸腔积液患者,其中良性胸腔积液患者30例,恶性胸腔积液患者50例。采用电化学发光法检测CYFRA21-1、CA19-9和CEA,并对其水平及阳性率进行统计学分析。结果 50例恶性胸腔积液患者的CYFRA21-1、CA19-9和CEA水平及阳性率均显著高于良性胸腔积液患者,差异均具有统计学意义(P均<0.05)。三项指标联合检测的敏感性、特异性、阳性预测值、阴性预测值和Youden指数均高于各项指标单独检测。结论肿瘤标志物CYFRA21-1、CA19-9、CEA可作为诊断恶性胸腔积液的指标,联合检测对于鉴别良恶性胸腔积液具有较高的诊断价值,可为临床制定合理治疗方案提供科学依据。Objective To discuss clinical value of detection and combined detection of cytokeratin fragment antigen 21-1 （CYFRA21-1）, CA19-9 （carbohydrate antigen 19-9） and carcino-embryonic antigen （CEA） in the identification between benign and malignant pleural effusion. Methods 80 cases pleural effu- sion patients were collected in,our hospital from October 2013 to October 2015, which were divided into 30 cases benign pleura! effusion patients and 50 cases malignant pleural effusion patients. Levels of CYFRA21-1, CA19-9 and CEA were detected by electrochemiluminescence immunoassay. And all data were analyzed sta- tistically. Results Levels and positive rates of CYFRA21-1, CA19-9 and CEA in malignant pleural effusion patients were all higher than that of benign pleural effusion patients, and the differences all had statistical sig- nificance （Pall〈 0.05）. The sensitivity, specificity, positive predictive value, negative predictive value and Youden index of combined detection were all higher than that of single detection. Conclusion CYFRA21-1, CA19-9 and GIlA can be used as the index to diagnosing malignant pleural effusion. And combined detection has higher diagnosis value in the identification between benign and malignant pleural effusion.

关 键 词：良恶性胸腔积液 细胞角蛋白片段 糖链抗原19-9 癌胚抗原 联合检测 

分 类 号：R730.43[医药卫生—肿瘤]