丹参酮对晚期非小细胞肺癌患者凝血指标与临床效果的影响研究  

Effect of Salvia Miltiorrhiza on Coagulation Parameters and Clinical Effect in Patients with Advanced Non Small Cell Lung Cancer

作　　者：朱业靖[1] 

机构地区：[1]山东省菏泽市立医院药学部,山东菏泽274031

出　　处：《中国医药指南》2016年第6期1-3,共3页Guide of China Medicine

摘　　要：目的探讨丹参酮对非小细胞肺癌(NSCLC)高凝状态的改善作用。方法选取2012年1月至2015年6月菏泽市立医院收治的NSCLC合并血液高凝状态患者120例,按照随机数字表法分为观察组和对照组各60例,两组均给予常规抗肿瘤及对症处理,观察组给予丹参酮胶囊口服,以2周为1个疗程。观察治疗前后血小板、血凝指标、临床症状积分及KPS评分变化。结果 1治疗后对照组的血浆FBI、D-D、FDP水平较治疗前升高,而观察组较治疗前明显降低,差异具有统计学意义(P<0.05);2对照组治疗后临床症状积分与治疗前比较差异无统计学意义(P>0.05);观察组治疗后临床症状总积分较治疗前明显改善,主要体现在体倦乏力和舌暗瘀斑方面,差异具有统计学意义(P<0.05);观察组临床症状疗效总有效率为93.33%,对照组临床症状疗效总有效率为78.33%,观察组有效率显著高于对照组,有统计学差异(P<0.05)。结论丹参酮在改善NSCLC患者的血液高凝状态方面效果明显,并可明显缓解临床症状,值得临床推广应用。Objective To investigate the effect of the improvement of the high coagulation state of the non small cell lung cancer（NSCLC）.Methods 120 patients with NSCLC complicated with high blood coagulation status in Heze Municiple Hospital from January 2012 to June 2015,were randomly divided into observation group and control group,60 cases in observation group and control group,two groups were given conventional anti tumor and symptomatic treatment.The changes of platelet,blood coagulation index,clinical symptom score and KPS score were observed before and after treatment.Result（1） plasma FBI,D-D and FDP levels in the control group were significantly higher than those before treatment,while the observation group was significantly lower than before treatment,the difference was statistically significant（P〈0.05）;（2） there was no significant difference in clinical symptom scores between the control group and the treatment group（P 〉0.05）;The total score of clinical symptoms were observed after the treatment group compared with those before treatment significantly improved,mainly reflected in the body tired asthenia and tongue dark ecchymosis on,the difference has statistical significance（P〈0.05）;The total effective rate of clinical symptoms in observation group was 93.33%,and the total effective rate was 78.33% in the control group,the observation group was significantly higher than the control group,there was a statistically significant difference（P〈0.05）.Conclusion The effect of Salvia miltiorrhiza on improving the blood coagulation state of NSCLC patients is obvious,and it can obviously relieve clinical symptoms,it is worthy of clinical application.

关 键 词：非小细胞肺癌 高凝状态 凝血指标 丹参酮 

分 类 号：R734.2[医药卫生—肿瘤]