血清sTWEAK水平与冠心病患者冠状动脉斑块稳定性、病变严重程度的关系  

作　　者：贾方[1] 王彦军[1] 朱琳[1] 俞天虹[1] 孙建辉[1] 

机构地区：[1]江苏省常州市第一人民医院心内科,江苏常州213003

出　　处：《中国药业》2015年第B12期156-157,共2页China Pharmaceuticals

摘　　要：目的探讨冠心病患者血清可溶性肿瘤坏死因子样凋亡弱诱导因子（sTWEAK）的表达及临床意义。方法选取因胸闷、胸痛入住心内科患者110例．根据冠脉造影结果临床表现将其分为急性冠脉综合征组（ACS组）33例、稳定性心绞痛组（SAP组）32例和对照组45例。比较3组间的临床资料、血清sTWEAK水平，分析sTWEAK与不同类型冠心病之间的相关性，并观察其与Gensini积分的关系。结果ACS组血清sTWEAK水平高于对照组及SAP组（P〈0．05），SAP组血清sTWEAK水平与对照组无明显差异（P〉0．05）：冠心病患者血清sTWEAK水平与Gensini积分呈正相关（r＝0．233，P〈0．05）。结论sTWEAK不仅能对粥样斑块稳定性具有提示性．且与冠脉病变程度呈正相关。Objective To explore the correlation between serum soluble tumor necrosis factor-like weak inducer of apoptosis （sTWEAK） levels and coronary atheroselerotic plaque stability, coronary lesions severity in patients with coronary heart disease （CHD）. Methods 110 enrolled patients were divided into acute coronary syndrome （ACS） group （33 cases）, stable angina pectoris （SAP） group （32 cases） and control group （45 cases） according to the clinical manifestation and angiographic results. Serum sTWEAK levels measured by enzyme linked immunosorbent assay （ELISA） were compared among the groups. The correlation between serum sTWEAK level and CHD was analyzed. The association of sTWEAK with Gensini score was studied. Results The serum sTWEAK levels in ACS group were higher than that in control and SAP groups （P 〈 0.05）. No significant difference was found in SAP group and control group （P 〉 0.05）;Statistically significant correlation was observed between sTWEAK level and Gensini score （r=0.233, P 〈 0.05）. Conclusions Serum sTWEAK level was positively correlated with atherosclerotic plaque stability and coronary lesions severity in patients with CHD.

关 键 词：可溶性肿瘤坏死因子样凋亡弱诱导因子 冠心病 斑块稳定性 GENSINI积分 

分 类 号：R363.2[医药卫生—病理学]