精神分裂症患者健康同胞感觉门控的脑功能磁共振成像研究  

The functional magnetic resonance imaging(fMRI) study of auditory sensory gating in the siblings of schizophrenic

作　　者：冀宾[1,2] 梅维[2,3] 卓永宁[4] 马树华[2,3] 景举珍[2,3] 伍秋林[2,3] 

机构地区：[1]汕头市第二人民医院放射科,汕头515011 [2]广东省医学分子影像重点实验室 [3]汕头大学医学院第一附属医院 [4]汕头大学精神卫生中心

出　　处：《中国神经精神疾病杂志》2015年第11期641-645,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省科技计划项目(编号:2008B030301367);国家自然科学基金面上项目(编号:81072905)

摘　　要：目的研究精神分裂症患者未患病同胞的感觉门控脑功能活动,以探讨精神分裂症感觉门控异常遗传内表型的神经影像学表现。方法对12名首发精神分裂症患者的未患病同胞及12名年龄、性别、受教育程度相匹配的正常对照进行脑功能磁共振成像,并采用多声音刺激和单声音刺激激活脑区,以两种声音刺激下脑激活程度差值反映听觉感觉门控功能,比较两组间听觉感觉门控脑功能激活程度的差异。结果同胞组的感觉门控脑激活在右侧中扣带回(x=4,y=8,z=32)、左侧前扣带回(x=-8,y=4,z=28)大于对照组(P<0.005,体素集合>10个)。结论精神分裂症患者未患病同胞的感觉门控异常表现为扣带回异常激活,提示感觉门控异常可能是精神分裂症的一项遗传内表型标志。Objective To investigate auditory sensory gating potential in the siblings of schizophrenic, to discover the neuroimaging features of sensory gating associated with schizophrenia as intermediate phenotypes. Methods Twelve siblings of schizophrenia patients in the first episodic, and 12 healthy controls matched in gender, age, education under- went MRI scan when performing a auditory sensory gating fMRI task （repeated clicks and single click auditory stimuli）. The measure of sensory gating was the contrast of repeated clicks minus single click. The analysis of result was imple- mented in SPM2. Results Compared with healthy controls, schizophrenia patients showed significant overactivation in the right inter cingnlate gyrus （x=4, y=8, z=32） and left anterior cingulate gyrus （x=8, y=4, z=28） during the fMRI sensory gating task. Conclusion Sensory gating is overactivated in the cingulate gyrus in siblings of schizophrenic. This pattern may be a potential endophenotype of schizophrenia.

关 键 词：精神分裂症 健康同胞 感觉门控 功能磁共振成像 

分 类 号：R749.3[医药卫生—神经病学与精神病学]