MicroRNA表达与舌鳞癌患者预后的关系及其调控舌鳞癌生物学行为的机制  

Relationships between microRNA expressions and prognosis in patients with tongue squamous cell carcinoma and the mechanisms microRNA regulating tongue squamous cell carcinoma biological behavior

作　　者：贾凌飞[1,2] 甘业华[2] 俞光岩[1] 

机构地区：[1]北京大学口腔医学院.口腔医院口腔颌面外科,北京100081 [2]北京大学口腔医学院.口腔医院中心实验室,北京100081

出　　处：《北京大学学报（医学版）》2016年第1期5-9,共5页Journal of Peking University:Health Sciences

摘　　要：舌鳞状细胞癌（tongue squamous cell carcinoma,TSCC）简称舌鳞癌,是口腔颌面部最常见的恶性肿瘤之一,恶性程度高,侵袭性强,易发生颈淋巴结转移^（[1]）。MicroRNA（miRNA）对多种恶性肿瘤的生物学行为起重要的调控作用^（[2-3]）。近年来,本课题组对部分抑癌相关miRNA,如miR-195/34a/26a/375/29b与舌鳞癌患者预后的关系以及调控舌鳞癌细胞增殖、周期、迁移、侵袭等生物学行为的分子机制进行了研究，现将其主要结果及意义作一综述。Tongue squamous cell carcinoma （TSCC） is the most common type of oral cancer and is well known for its high rate of proliferation and lymph nodal metastasis. Exploring the underlying path- ways regulating TSCC could provide novel ideas for diagnosis and prognosis of TSCC patients, as well as molecular targets for treatment of TSCC. MicroRNAs （miRNAs） are small noncoding RNAs that inhibit gene expression through the 3＇ untranslated regions （3 ＇UTRs） of their target messenger RNAs. They play crucial roles in numerous biological processes, including cancer progression. Although great efforts have been made, what role miRNAs may play in the early detection and diagnosis of TSCC is not fully under- stood. Recently, our team has performed a series of basic and clinical researches in an attempt to investi- gate the relationships between miRNA expressions and prognosis of patients with TSCC and the mecha- nisms under regulation of TSCC. The results showed that miR-195, miR-34a, miR-29b, miR-375 and miR-26a could inhibit TSCC cells progression and development via a sophisticated network of genes. Spe- cifically, the anti-tumor effects of miR-195 in TSCC may be partially mediated by its inhibition of Cy- clinD1 and Bcl-2 expression. The expression of miR-34a could inhibit migration and invasion of TSCC eel1 lines via targeting MMP9 and MMP14. The function of miR-29b may be through the miR-29b/Sp1/ PTEN/AKT axis. Overexpression of miR-375 inhibited Spl expression by targeting the 3＇ untranslated re- gion of the Spl transcript. MEG3 and miR-26a inhibited TSCC cell proliferation, cycle progression and promoted cell apoptosis and miR-26a could increase the MEG3 expression through reduction of the ex- pression of DNMT3B in TSCC. In light of the role of those miRNAs in diagnosis and prognosis of TSCC, we reported that decreased miR-195 and miR-375 expression was associated with poor overall survival rate of the TSCC patients, while miR-34a expression was negatively correlated with cervical lymph node me- tastas

关 键 词：舌肿瘤 癌 鳞状细胞 微RNAS 预后 肿瘤生物学行为 

分 类 号：R739.86[医药卫生—肿瘤]