头孢噻肟钠制备工艺的改进  

Improvement on Synthesis Process of Cefotaxime Sodium

作　　者：孙津鸽 高得瀛 刘红坤 李文杰 李志军 

机构地区：[1]河南康达制药有限公司,河南周口466200

出　　处：《山东化工》2016年第4期12-13,共2页Shandong Chemical Industry

摘　　要：为改进头孢噻肟钠制备工艺。在混合溶媒中,头孢噻肟酸与成盐剂反应制得头孢噻肟钠溶液,再滴加溶析剂析出头孢噻肟钠固体。制得头孢噻肟钠的含量稳定在96%以上,且目标产物经质谱和核磁共振确认结构。改进后的工艺优化了反应条件,提高了含量,降低了成本,更适合工业化生产。In order to improve the synthesis process of Cefotaxime sodium. Make solution of Cefotaxime Sodium by salifyingreaction of Cefotaxime acid in the mixed solvent, and then dropping dilution agent to make Cefotaxime Sodium precipitated.The content of the prepared Cefotaxime sodium is more than 96%. The structure of adefovir dipivoxil was cofifirmed by MSand 1 H- NMR. The research optimized the hasreaction conditions and enhanced receiving content and reduced the cost .So it more suitables for industrial production requirements.

关 键 词：头孢噻肟酸 头孢噻肟钠 成盐剂 工艺改进 

分 类 号：R914.5[医药卫生—药物化学]